Page 20 - Application Notebook - PFAS Analysis

Application No. C184
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Method Detection Limit to a final volume of 1 mL in 96:4 % methanol:water.
Nine such samples were pretreated over the course of
A Method Detection Limit (MDL) study was conducted three days. The results of the MDL study using the
by spiking the 250 mL water samples to obtain a LCMS-8045 and LCMS-8050 are tabulated (Table 6),
spiked concentration of 5 ng/L (5 ppt) for each PFAS. MDLs ranging from 0.7–3.3 ng/L and 0.7–1.6 ng/L,
These samples were then pretreated and concentrated respectively, were achieved.

Table 6. Results for Method Detection Limits (MDL) study using LCMS-8045 and LCMS-8050

LCMS-8045 LCMS-8050

Spiked
Compound Conc. Calculated Calculated
(ng/L) Conc. % % RSD MDL Conc. % %RSD MDL
(ng/L), n = 9 Recovery (ng/L) (ng/L), n = 9 Recovery

PFBS 5 4.2 83 12 1.5 5.1 102 8 1.2

4:2FTS^ 5 5.2 104 14 2.1 4.9 98 9 1.3

PFHxA 5 4.1 81 10 1.2 4.7 94 7 1.0

PFPeS^ 5 4.1 81 13 1.5 4.8 96 9 1.4

PFHpA 5 4.2 84 8 1.1 4.7 94 7 1.0

PFHxS 5 4.3 85 6 0.7 4.8 96 8 1.2

6:2 FTS^ 5 4.6 92 17 2.3 4.8 96 7 1.1

PFOA 5 4.6 92 12 1.6 4.7 94 7 1.0

PFHpS^ 5 4.0 80 9 1.0 4.7 95 11 1.6

PFOS 5 4.0 81 15 1.7 4.6 92 6 0.8

PFNA 5 4.0 80 7 0.8 4.8 97 5 0.7

8:2 FTS^ 5 5.0 100 22 3.3 5.3 106 11 1.7

PFNS^ 5 4.0 81 9 2.1 4.4 91 8 1.1

PFDA 5 4.1 83 8 1.0 4.8 95 10 1.4

N-MeFOSAA 5 3.9 78 15 1.7 4.6 91 9 1.2

N-EtFOSAA 5 3.8 77 11 1.2 4.4 88 10 1.3

PFDS^ 5 4.1 82 18 2.2 4.6 92 10 1.4

PFUnA 5 4.1 82 12 1.5 4.4 88 11 1.4

PFDoA 5 4.0 79 14 1.6 4.3 86 9 1.2

PFTriA 5 3.9 78 13 1.4 4.4 87 10 1.3

PFTreA 5 4.0 79 15 1.8 4.3 86 11 1.3

^Additional PFAS compounds not listed in EPA Method 537.