Page 24 - Application Notebook - PFAS Analysis

SSI-LCMS-102

EPA Method 537.1 analyzes 25 PFAS compounds including
4 surrogates and 3 internal standards. Target compounds
and their respective acronyms, surrogate compounds,
internal standards, and their chemical classes are listed in
Table 1. For the remainder of this application note, refer to
the acronyms in Table 1.

Table 1: Target compound list and acronyms

Acronym Compound Class
HFPO-DA Hexafluoropropylene oxide dimer acid PFECA
PFHxA Perfluoro-n-hexanoic acid PFCA
PFBS Potassium perfluoro-1-butanesulfonate PFAS
PFHpA Perfluoro-n-heptanoic acid PFCA
PFOA Perfluoro-n-octanoic acid PFCA
PFHxS Sodium perfluoro-1-hexanesulfonate PFAS
PFNA Perfluoro-n-nonanoic acid PFCA
PFHpS Sodium perfluoro-1-hexanesulfonate PFAS
N-MeFOSAA N-methylperfluoro-1-octanesulfonamidoacetic acid FOSAA
PFDA Perfluoro-n-decanoic acid PFCA
N-EtFOSAA N-ethylperfluoro-1-octanesulfonamidoacetic acid FOSAA
PFOS Sodium perfluoro-1-octanesulfonate PFAS
PFUdA Perfluoro-n-undecanoic acid PFCA
PFDoA Perfluoro-n-dodecanoic acid PFCA
PFDS Sodium perfluoro-1-decanesulfonate PFAS
PFTrDA Perfluoro-n-tridecanoic acid PFCA
11Cl-PF3OUdS 11-chloroeicosafluoro-3-oxaundecane-1-sulfonic acid PFES
9Cl-PF3ONS 9-chlorohexadecafluoro-3-oxanone-1-sulfonic acid PFES
ADONA P4,8-dioxa-3H-perfluorononanoic acid PFPE
Internal Standards
13C2-PFOA IS1
13C4-PFOS IS2
D3-NMeFOSAA IS3
Surrogates
13C2-PFHxA Surr1
13C2-PFDA Surr2
D5-NEtFOSAA Surr3
13C3-HFPO-DA Surr4
PFECA - Perfluoroalkyl Ether Carboxylic Acids
PFCA - Perfluorinated Carboxylic Acid
PFAS - Per- and Polyfluoroalkyl Substances
FOSAA – Perfluoroalkane Sulfonamido Substances
PFES - Perfluoroelastomers
PFPE - Perfluoropolyethers