Page 28 - Application Notebook - PFAS Analysis

SSI-LCMS-102

Method Detection Limit
A Method Detection Limit (MDL) study was conducted by Table 5 lists the average calculated sample concentration
spiking standards at 4 ppt. The Method Detection Limit as well as the Accuracy, %RSD, and the Method Detection
was calculated as described in 40 CFR Part 136 Appendix Limit.
B. The MDL for all targets listed in EPA Method 537.1
ranged from 0.48 ppt to 1.64 ppt. All compounds showed
%RSD of less than 20% with 8 injections.

Table 5: Method Detection Limit (MDL) results
Spiked Calculated %RSD MDL
Compound Accuracy
Concentration (ppt) Concentration (ppt) (n=8) (ppt)
PFBS 4 3.84 96.0 4.4 0.484
PFHxA 4 3.70 92.5 7.3 0.787
HFPO-DA 4 3.55 88.8 8.6 0.881
PFHpA 4 3.87 96.8 6.2 0.693
PFHxS 4 3.74 93.5 5.7 0.615
ADONA 4 3.72 93.0 5.4 0.585
PFOA 4 3.71 92.8 5.5 0.595
PFNA 4 3.79 94.8 5.2 0.566
PFOS 4 3.76 94.0 11.1 1.213
9Cl-PF3ONS 4 3.63 90.8 7.9 0.825
PFDA 4 3.67 91.8 5.7 0.602
N-MeFOSAA 4 3.55 88.8 15.9 1.637
N-EtFOSAA 4 3.81 95.3 7.3 0.808
PFUnA 4 3.56 89.0 10.2 1.052
11Cl-PF3OUdS 4 3.41 85.2 12.7 1.255
PFDoA 4 3.73 93.3 5.4 0.584
PFTriA 4 3.74 93.5 5.7 0.618
PFTreA 4 3.67 91.8 5.7 0.601