Page 23 - Application Notebook - PFAS Analysis

Liquid Chromatography Mass Spectrometry
Analysis of Per-and Polyfluoroalkyl Substances
(PFAS) Specified in EPA M537.1 Using the Triple
SSI-LCMS-102
Quadrupole LCMS-8045

Brahm Prakash, Gerard Byrne II, Ruth Marfil-Vega, Yuka Fujito, Christopher Gilles
Shimadzu Scientific Instruments, Inc., Columbia, MD 21046

■ Abstract
The EPA recently updated Method 537 to 537.1 to The EPA published EPA Method 537.1 in November of
incorporate the replacement PFAS introduced into the 2018, incorporating the replacement PFAS recently
market after PFOA and PFOS were phased out in the US quantified in drinking water: GenX (or HFPO-DA), ADONA,
market. This application note demonstrates that analysis for 11Cl-PF3OUdS, and 9Cl-PF3ONS. This method allows
all analytes listed in EPA 537.1 can be performed on the laboratories to assess occurrence of these new chemicals
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LCMS-8045, meeting the Quality Assurance and Quality together with the 14 original targets in drinking water .
Control criteria specified in the method. Recoveries were
greater than 80% for all compounds, with surrogate This application note summarizes the performance of the
recoveries within 10% of the true value. Method Detection Shimadzu LCMS-8045 for all analytes listed in EPA Method
Limits (MDL) were below 2 ppt for all the target analytes. 537.1. Results demonstrate that the instrument’s
performance exceeds the requirements outlined in the
■ Background method. Most importantly, results confirm that laboratories
Per- and Polyfluorinated Alkyl Substances (PFAS) are a currently analyzing samples by method EPA 537 (published
group of anthropogenic chemicals widely used in consumer in Shimadzu App Note No. C184 ) can easily update their
products (e.g. food packaging materials and non-stick workflow to implement EPA method 537.1 in their
coatings) and industrial applications (firefighting foams, instrument while maintaining the instrument’s
polymers/plastics manufacturing). Their unique properties, performance.
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such as being highly stable and resistant to degradation ,
together with their ubiquitous use, have resulted in the Keywords: Per- and Polyfluorinated Alkyl Substances,
accumulation of PFAS in the environment. PFAS, Perfluorinated Compounds, PFCs, Drinking Water,
PFOA, PFOS, Persistent Organic Pollutants, POPs, GenX,
EPA Method 537 was originally published in November of Triple Quad Reference original app note/news
2009 and focused on 20 PFAS (14 targets, 3 surrogates, 3
internal standards). Since then, a change in PFAS
manufacturing practices led to PFOA and PFOS being
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phased out in the United States .