Page 54 - LC-SFC_Pharma_Brochure

Solution 7: Online UHPLC for Dissolution Testing

Dissolution analysis is widely used in drug development and quality control. The online analysis of dissolution apparatus
and UHPLC can greatly simplify the dissolution test operation and improve work efficiency. This combination has been
increasingly recognized by chemists in the pharmaceutical industries.
However, the existing online systems in the market still have issues with sample dilution, sample preparation, carryover, etc.
Furthermore, the analysis speed of LC cannot match the progress of the dissolution test.

The Nexera FV system, developed exclusively by Shimadzu, really helps you seamlessly connect from dissolution testing to
LC analysis.

Nexera FV

Fraction Analysis Mode Dissolution
Tester

Fractionate Analyze

Direction Injection Analysis Mode Dissolution

Tester

 Fully automated  Fast and continous Analyze  Intelligent
workflow analysis Directly dissolution
report

New online Dissolution Apparatus - UHPLC System

• The newly designed Nexera FV autosampler is directly connected with the dissolution tester to realize the automation of the whole
process from sampling to data acquisition and result report.

• The Nexera FV system, which possesses high speed, stability, powerful automatic dilution and sample preparation function of
Nexera X2, is even more powerful and capable in obtaining highly reliable dissolution test results.
Significantly improve the efficiency of dissolution analysis

• Fully automated workflow reduces the amount of manual transfer and dilution of the sample, as well as possible human error.

• The high speed of UHPLC with the online coupling of the Nexera FV allows non-stop and uninterrupted dissolution-LC batch
analysis. This online system is proven to be effective for the sustained release preparation.