Page 59 - LC-SFC_Pharma_Brochure

Solution 8: Quantitative Data Processing

As analytical instruments get faster, equipped with automation capabilities and can operate round the clock, data are
being generated at a much faster rate. To keep up to speed and improve the laboratory productivity, more efficient,
reliable and accurate data processing is required.
The reliability of chromatographic quantification is greatly influenced by the integration repeatability problems caused
by noise, drift and erratic baseline, as well as the efficiency and regulatory compliance issues associated with manual
integration. Meanwhile, in drug analysis, the wide disparity and great changes of concentration bring some difficulties to
the rapid and accurate quantification of different components.

Shimadzu LabSolutions software provides a variety of automated chromatographic peak integration algorithms and data
processing functions, which can easily achieve accurate quantitative analysis of all types of chromatographic data.

i-PeakFinder

 Highly accurate detection  Peak detection at low  Automatic determination
of shoulder peaks S/N levels of baseline undulation and drift

 Automatic tracking of peak  Automatic tracking of noise
width variation intensity changes

A new automated chromatographic peak integration algorithm

• i-PeakFinder, a new peak integration algorithm for LabSolutions, is a completely automated integration function that can detect
peaks with high levels of accuracy without requiring special parameter adjustments.

• This algorithm has adjustable parameters that allow the integration function to be applied to a wide range of complex
chromatogram patterns. Furthermore, the adjustable parameters allow to output highly accurate peak integration results from
large quantities of data, even for batch analysis.
Easily calculate peak areas in complex baselines

• For hidden shoulder peaks and impurity peaks seriously interfered by main peaks, no complex time program and other parameter
settings are needed, and accurate integration results can be obtained quickly.

• Faced with a variety of complex peak shapes, as well as baseline fluctuations and drift, the consistent peak detection sensitivity can
be automatically maintained throughout the chromatography, thus obtaining better peak area reproducibility results.