Page 12 - Shimadzu EPMA-8050G

Applications

Distribution of Ag and Cu in Lead-Free Solder Metallic Elements in Biological Tissues (DDS)
This data is from a mapping analysis of areas in lead-free solder containing a large amount of Ag. This EPMA element imaging data shows the existence of platinum (Pt), a component (platinum
(Accelerating voltage: 10 kV; beam current: 20 nA) The shape of the particles in the Ag X-ray complex) of the anticancer drug carboplatin, delivered (by a DDS) into the tissue of a head and
image agrees well with the shape of the particles in the BSE image (COMPO). It is evident that the neck tumor in a mouse.
particles with a diameter of about 0.1 m, indicated by the red dashed lines, are also Ag particles. By binding with DNA strands, the genetic substance inside the cancer cells, the carboplatin
In addition, the existence of Cu-containing particles can also be confirmed, as shown by the yellow prevents cell division (DNA replication), destroying the cells. The element imaging clearly shows the
dashed lines. manner in which the anticancer drug is delivered within the cancer cells.

COMPO 1µm Ag 1µm

5µm

Cu
1µm

Pt
5µm

EPMA-8050G
Electron Probe Microanalyzer
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