Page 33 - LC-SFC_Pharma_Brochure

Prominence UFPLC

A true complete purification system: from mixtures to high-purity compounds
• The brand new Prominence UFPLC is the ready-to-use system package for online coupling of preparation and purification. All
preparative processes can be performed online, from fractionation to concentration, purification, and recovery.

• The flexibility of modular configuration allows online purification of up to 5 components detected in the fractionation step,
facilitating the evaluation of sub-components and impurities.

Collect high purity products effortlessly

• Easily eliminate counter ions and low volatility solvents in the prepared distillate to recover high purity and stable powdered
samples.

• This exclusive technology ensures that the water carried in the distillate is sufficiently removed in a short period of time, greatly
reducing the time required for solvent removal, purification and powdering.

Isolates fraction containing target peaks
and concentrates it in a trap column

Removes impurities and pair ions

Target
compounds Fractionation/
Pair ion concentration
(ex TFA)
Sample containing
target components Purification
Elutes components
using organic solvent
Elution

One System Handles It All
Prominence UFPLC
Recovery of target
compounds
in high-purity liquid
30 min 20 min 10 - 40 min
Takes only
Concentrate
Concentrate
Synthesis Fractionation and Powderization one and half
and
Purify
Purify hours
Mobile
phase-derived Short because
no water is
components contained
removed
Untreated Sample Treated Freebase Form

 Easily removes previously
TFA / Hydrochloride
(0.13% / 0.08%)
Cl − difficult-to-eliminate counter
Hydrochloride TFA ions and low-volatility solvents
(56%) (44%)
Freebase
(99.79%)

Cl − TFA −
TFA −