Page 6 - LifeScience Solutions for Stem Cell Analysis

Comparative Metabolomics Comparative Metabolomics of
of Human ES Cells
Human ES Cells
GC-MS

˙ Introduction
Proteomic Analysis of Human iPS Cell Differentiation Human embryonic stem cells (hESCs) have the potential not only to proliferate

indefinitely but also to differentiate into any cell type in the body. These properties
make hESCs promising for applications such as drug testing, disease modeling, and
cell replacement therapy.

Among all “omics” technologies, a metabolomics approach is one of the most
powerful approaches because useful information about the change of metabolic
Comparative Metabolomics of Human ES Cells additives for differentiation of the stem cells.
pathways is obtained, as well as information leading to the discovery of quality
control markers of hESCs useful for large scale cell culture and the study of medium

GC-MS-based metabolomics studies have been conducted since the beginning of metabolomics, and GC-MS is still a powerful
technology for metabolomics. The reasons include the existence of many databases for MS spectra, which lead to easy
interpretation of experimentally obtained MS spectra, and the high resolution separation performance of GC, which is useful for
the separation of complex biological mixtures.
A Micro-fluidic Approach using a Super-functional Liver Chip Shimadzu offers the GCMS-QP2010 Ultra, our most advanced Single Quadrupole gas chromatograph mass spectrometer.

GCMS-QP2010 Ultra

The successor to the GCMS-QP2010 Plus, it features best-in-class scan speed and sensitivity.

Metabolomics by LC-MS/MS

Tissue Imaging by MALDI

Shimadzu’s Mass Spectrometers Gas Chromatograph-Mass Spectrometer

GCMS-QP2010 Ultra

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