Page 8 - Shimadzu Co-Sense Series

Co-Sense for Impurities

Basic Concept of Co-Sense for Impurities

Co-Sense for Impurities offers both two-dimensional high the first dimension separation or other general-purpose
separation chromatograply along with high sensitivity. It is columns can be used as the trap column in two-dimensional
especially useful for high-sensitivity analysis of ultra trace reversed phase plus reversed phase separation. It can also be
components or for analyzing components in complex matrices. used for more complicated two-dimensional separation, such as
The system uses trap concentration and on-line dilution after normal phase plus reversed phase separation.
the first dimension separation. That means a guard column for

Co-Sense for Impurities Configuration

In Co-Sense for Impurities, samples are first eluted through the first dimension separation column, through the first switching valve
and subsequently through the trap column. This is on the timing of target component elution, where target components are reliably
concentrated in the trap column while being diluted on-line. Next, by valve switching, the target components concentrated in the
trap column are introduced to a second dimension separation column, where the samples are further separated and then detected.
Pump unit for first dimension separation
Autosampler First dimension
separation column

Concentration column

Pump unit for on-line
concentration

Second dimension
Detector
separation column
Pump unit for second
dimension separation

Software for Co-Sense for Impurities

Control software designed specifically for Co-Sense for
Impurities allows specifying settings separately for the first
dimension separation, trap conditions, and second dimension
separation in a manner similar to standard LC controls. It also
allows visually monitoring the system status, mainly involving
the mobile phase flow status. Therefore, it allows easily and
accurately understanding the status of each flow line during
analysis or cleaning.

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