Page 30 - Oligonucleotide Therapeutics Solution Guide

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TORAST-H Series This is a series of high-end consumables that Shimadzu GLC has
evaluated and verified using the latest technology.

Original Low Adsorption Vial Original Low Adsorption Polypropylene Vial Modification

TORAST-H Glass Vial TORAST-H Bio Vial Target selection

benefits

• Minimized adsorption of bases, acids and neutrals benefits
• Two sizes are available (1.5 mL and 150 µL) Unprotected Excision
• Superior Quality Control (Comes with quality certicates for • Easy-to-use, user-friendly design Oligomer synthesis
lot management)

Low Adsorption for Long-term Storage Adsorption Test Using Trypsin Digestion Products of Myoglobin (approx. 1.9 pmol/mL)

When a sample is stored in a general vial for a long time, the sample may adsorb into the surface of the vial, causing the reproducibility to be poor. The results confirmed the phenomenon that highly polar peptides with retention times detected between approx. 7 and 8 minutes mostly adsorb to glass
The TORAST-H Glass Vial contains low adsorption characteristics that makes it excellent for long term sample storage. vials, whereas highly hydrophobic peptides with retention times detected between approx. 12 and 16 minutes mostly adsorb to polypropylene (PP) vials. Purification

TORAST-H-
Glass Vial
Glass Vial A

Glass Vial B

Glass Vial C Quality Control Characteristic analysis

* The area value at 0 h of polypropylene (PP) vial (control) was regarded as 100%, and each area value was compared.
The recovery rate of PP vials after 3 months was 89%, which was lower than that of TORAST-H glass vials.
Exterior Design that Enables Using Vials Directly for Flash Centrifugation

Before Centrifuge After DDS
Product Name Specification Cap Slit Volume Qty. P/N Pharmacokinetics
Droplets
glass, clear, label and filling lines － 370-04300-01 Sample loss
（wide open 9-425） ＋ 370-04300-02
1.5 mL
glass, amber, label and filling lines － 370-04300-03 Air entrapment
TORAST-H Glass Vial （wide open 9-425） ＋ 370-04300-04 Prevents specified injection
(PTFE, Including vials, caps and
septum, cetification of inspection) glass, clear, label and filling lines Screw, Black － 100 pcs. / pack 370-04301-01
（wide open 9-425） ＋ 370-04301-02
150 µL Product Name Specification Slit Volume Qty. P/N
glass, amber, label and filling lines － 370-04301-03 Other
（wide open 9-425） ＋ 370-04301-04 TORAST-H Bio Vial PP Vial Yes 300 µL 100 370-04350-00
Screw Cap for PTFE / silicone septum － 370-04310-01 If using a Shimadzu i-Series LC system, use the special vial detection plate (P/N: 228-51891-03) shown to the right..
TORAST-H Glass Vial （wide open 9-425） ＋ － 370-04310-02

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