Page 4 - LC-SFC_Pharma_Brochure

Solution 1: LC Method Development

For drug research and analysis, LC method development is often the time-limiting factor.

The manual optimization of chromatographic parameters such as mobile phases, columns and gradient elution program, is
tedious, time and labor intensive. The parameters may not even be optimal and could likely affect the evaluation of drug
quality.

Shimadzu offers a smarter solution for LC method development for a more cost-effective workflow for your drug research
and analysis.

Nexera Method Scouting System

1) Define your 2) Automatic method 3) Evaluate and identify the method
analytical conditions screening with with the optimal resolution value
different conditions
Resolution value Rank
No. of X No. of Method 1 140.012 4
Mobile Columns Gradient Mobile Phases Columns Method 2 120.213 5
Phases Conditions Method 3 290.057 1
= No. of Screening Method 4 289.281 2
Combinations Method 5 100.901 6
Method 6 250.783 3
Suitable for all type of LC systems
Improved features and fully compatible with more systems Suitable for all type of LC systems
Nexera X2 i-Series Nexera UC
• The Nexera Method Scouting System supports all Nexera • Method scouting for chiral
• Automatically verify 192 sets
• Save space and save cost
and i-Series products and configurations. Omni-directional compounds
of conditions @ 130 MPa
screening is performed by a combination of automatic Nexera X2
• Examine different pH by
• LC/SFC switching, improved
change the mobile phase
efficiency for method
switching and permutation of more columns and mobile • Automatically verify 192 sets
of conditions @ 130 MPa
development
phases. • pH simulation in the method
for given mobile phase
• The new software with an effective user interface enables compositions

parameters and evaluation options.
Establish a LC method quickly and accurately
i-Series
• Instrument runtime, manual operation time and data • Save space and cost
processing time are greatly reduced thanks to the automated
system and easy-to-use operating software.
• The innovative scientific evaluation software helps you to select
the best separation conditions automatically and accurately
from the massive analysis results.
Nexera UC
• Method scouting for chiral
compounds
• LC/SFC switching, improved
efficiency for method
development