Page 10 - 2023 Shimadzu Analytical and Measuring Instruments

Liquid Chromatographs

Nexera Application System Ultra High Performance Liquid Chromatograph for Online Dissolution Testing
Nexera GPC System Nexera FV

Chromatography Systems

By combining the superior solvent delivery and sample injection Nexera FV systems automate process steps ranging from dispensing and
performance of the Prominence series with a temperature-controlled analyzing solutions eluted from dissolution testing systems to generating
detector, this system achieves rapid baseline stabilization and reports. Two analysis modes are available, either of which can be selected to
outstanding reproducibility of analytical results, which results in significantly reduce the labor involved in dissolution testing. The fraction analysis
providing highly reliable data. Convenient features, such as an mode supports high-speed sampling at five-minute intervals for formulations
overlapping injection function and automated analysis workflow, help that dissolve quickly, whereas the direct analysis mode immediately analyzes the
increase productivity for routine GPC measurements. The system is also solutions eluted during the specified sampling interval, such as for analyzing
able to recycle mobile phase from intervals where no components are sustained-release formulations with long sampling intervals. That means reliable
eluted,* which minimizes any environmental impact. dissolution testing results can be obtained quickly with systems configured
* Using a solvent recycle valve (optional). based on Nexera series models, which have earned a reputation for speed,
CBM-40, LC-40D, DGU-403, SIL-40C, CTO-40C, RID-20A, sensitivity, and stability. Because Nexera systems can also be used as a regular
Major component units
LabSolutions LC, LabSolutions GPC software, and others UHPLC system, the ability to use them for fast analysis can be expected to
Brochure No. C190-E092 increase instrument uptime rates at sites using them for testing.
Major component units CBM-40lite, LC-40D X3, DGU-405, SIL-30ACFV, CTO-40C,
SPD-40, LabSolutions LC, and others
Brochure No. C190-E214
Ultra High Speed LCMS System for Multiplex Analysis Comprehensive Two-Dimensional Liquid Chromatograph
Nexera MX Nexera-e New

Nexera MX systems offer up to double the LCMS sample processing Comprehensive 2D-LC methodology is a paradigm shift in liquid
capacity. In addition to separating and detecting injected samples, chromatography separation. By combining two independent separation
LCMS analysis normally also requires various other processing steps, modes orthogonally in combination with a dual-loop/dual-valve alternate
such as rinsing the column, equilibrating the column at the initial mobile switching design, the highest possible peak capacity is achieved. The new
phase concentration, rinsing the autosampler, injecting the next sample, Nexera-e is the ideal solution for the separation and characterization of
and so on. Therefore, to increase analysis throughput, there has been a most challenging and complex samples. It enables comprehensive data
need for solutions that shorten the time required for the above non- collection by analyzing at an extremely low flow rate in the first dimension
data acquisition processes. The Nexera MX features the unique Nexera and ultra-high speed in the second dimension. The Nexera is equipped with
MX Dual Stream Technology (MX-DST) that can maximize LCMS data the “Auto-Diagnostic” function, which monitors baseline changes and
acquisition efficiency by alternating between two streams used to inject pressure fluctuations to check for abnormalities. When it detects an unusual
samples into the LCMS system. fluctuation, it can automatically pause the analysis. This feature prevents the
SCL-40, LC-40B XR×2, DGU-405, DGU-403, SIL-40C XR, loss of valuable samples due to abnormal pumping. It provides exceptionally
Plate Changer, CTO-40C, Startup kit, LCMS-8060NX,
Major component units high separation not possible with conventional HPLC systems, so that target
LabSolutions LCMS/Insight, LabSolutions Connect MRM,
and others components can be accurately detected in complex samples, such as
Brochure No. C190-E190 impurities in pharmaceuticals, enzyme digested substances from proteins,
natural substances, including food extracts, and synthetic polymers.
10 Brochure No. C190-E172