Page 9 - 2023 Shimadzu Analytical and Measuring Instruments

Liquid Chromatographs

New Ultra High Performance Liquid Chromatograph

Nexera XS inert Chromatography Systems

EXPERIENCE NEWFOUND CLARITY
Acquiring highly reliable data with a standard UHPLC system that uses
stainless steel parts can be difficult due to the adsorption of small and
medium-sized metal-coordinating compounds such as oligonucleotides
and compounds with phosphate groups to metal surfaces. Mobile
phases with high salt concentrations and extreme pH levels can also Mass Spectrometry Systems
lead to the corrosion of stainless steel parts. Nexera XS inert is a UHPLC
system (resistant to 105 MPa) that uses non-metal materials in wetted
flow lines. This reduces adsorption of metal-coordinating compounds in
flow lines and improves peak shapes, thereby improving peak
separation, sensitivity, and quantitative accuracy in LC and LC/MS
analysis. The use of non-metal materials also eliminates the risk of flow
line corrosion by mobile phases and resolves system durability issues.
The optional pHM-40 pH monitor stores mobile phase pH data gathered Life Science Lab Systems
in real-time as a data file for even greater data reliability and traceability.
SCL-40, LC-40D XSi, SIL-40C XSi, CTO-40S, SPD-M40,
Major component units
Low pressure gradient unit, pHM-40, LabSolutions LC, and others
Brochure No. C190-E275
Assured Reliability and Reproducibility Movies >
Standard UHPLC mAU Nexera XS inert mAU
(stainless steel-based) 30 AMP 30 ADP AMP
Material
Metal-sensitive Poor peak shape that inhibits ATP Sharp peaks Spectroscopy Systems
compounds 20 ADP adsorption 20
Peak tailing Excellent separation
10 10
Adsorption to
internal surface 0 0
Stainless steel tubing 0.0 1.0 2.0 3.0 4.0 5.0 6.0 7.0 min 0.0 1.0 2.0 3.0 4.0 5.0 6.0 7.0 min
High Performance Liquid Chromatograph Ultra High Performance Liquid Chromatograph Nexera
Nexera lite inert New Method Scouting System Systems X-ray and Surface Analysis

Nexera lite inert is an HPLC system (up to 20 MPa with aqueous mobile Nexera Method Scouting System is constructed with the objective of Measurement Systems Environmental
phases) that produces reliable data for size exclusion chromatography automating and shortening the time required for the analysis method
and ion exchange chromatography even when running mobile phases development process. With this system, data is automatically acquired
with high concentration haloid salts and using methods with extreme using a maximum of 192 (16 times 12) method combinations based on Systems Non-Destructive Inspection Material Testing and
mobile phase pH levels. HPLC systems with stainless steel parts must be 16 (4 times 4) mobile phase solvents and 12 columns. This enables a
cleaned immediately with pure water after running these types of comprehensive investigation of analysis conditions while shortening the
mobile phases, but Nexera lite inert uses non-metal materials in wetted total time required for method searches. Using the mobile phase
flow lines, thereby preventing rust-related issues and ensuring stable blending function to investigate mobile phase composition and
long-term operation. The use of non-metal materials in flow lines also FlowPilot to protect the column during automated equilibration
prevents the adsorption of metal-coordinating compounds and helps significantly improve the efficiency and reliability of your analytical
improve peak shapes and peak separation. Nexera lite inert supports a method development.
wide variety of system configurations for high-pressure and low- Major component units SCL-40, LC-40D X3×2, DGU-405×2, SIL-40C X3, Measurement Systems Physical Properties
pressure gradients, mobile phase blending, and other conditions. CTO-40C, SPD-M40, LabSolutions LC, and others
• Configuration also possible with Nexera XS inert
CBM-40lite, LC-40i, DGU-403, SIL-20AC (inert kit), CTO-40C,
Major component units SPD-40, LabSolutions LC, and others Brochure No. C190-E216
Brochure No. C190-E292
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