Page 14 - 2_Pharmaceutical industry
P. 14
SCA-130-206
instance in cleaning validation) to highly
polluted waters (such as wastewaters).
Shimadzu TOC-Systems.
Both types of instrument with their different
oxidation methods can be used for TOC
determination in accordance with the new
United States Pharmacopeia (USP <643>)
and the European Pharmacopeia (EP 2.2.44).
The advantage of the combustion method is
its high oxidation potential, especially for
samples containing particulate matter.
Moreover, simultaneous TOC/TN b
measurements can be carried out, leading to
a higher information content of the analysis.
The advantage of wet-chemical oxidation is
Figure.1 : Calibration Curve, Sucrose 8mg/L its very high injection volume, which leads to
higher sensitivity and therefore enables high
Additional modifications of the TOC system precision measurements in the lower ppb
are not necessary. range.
■ Shimadzu TOC-System ■ Recommended Analyser / Configuration
Shimadzu offers two systems that are ideally TOC-L CPH with high sensitive catalyst
suitable for TOC determination in ultrapure ASI-L (40ml), external sparge kit
water. The TOC-VWP/WS uses wet-chemical
oxidation, whereas the TOC-LCPH uses TOC-V WP
catalytic combustion at 680 °C. With their ASI-V (40ml), external sparge kit
wide measuring range of 0.5 µg/L up to
30,000 mg/L, the instruments support any
application – from ultrapure water (for
Figure. 2: SST, Benzochinone 8mg/L
