Page 8 - Shimadzu LCMS-8060
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The triple quadrupole LCMS-8060 has an advanced ion guide design to increase ion production and detection and makes a meaningful
                                                                                                                                      impact on high sensitivity detection.


                                                                                                                                      High-Sensitivity Quantitation of Verapamil in Plasma


                                                                                                                                               Verapamil in plasma; 100 ag on column
                                                                                                                                          (%)                                                        Precision and accuracy of verapamil
                                                                                                                                               ESI positive; m/z 455.40 > 165.00   CE: -27V
                  Expand your capabilities in quantitation                                                                                                                                      Actual Conc.  Calculated Conc.  Area RSD  Accuracy
                                                                                                                                                                                                 (ng/mL)
                                                                                                                                                                                                                  (%, n=3)
                                                                                                                                                                                                                            (%)
                                                                                                                                                                                                          (ng/mL)
                  Ultra sensitive detection                                                                                                                     %RSD 5.08% (n=10)                0.0001  0.000100  2.97     100.3
                                                                                                                                                                                                         0.000508
                                                                                                                                                                                                 0.0005
                                                                                                                                                                                                                   6.15
                                                                                                                                                                                                                            101.7
                                                                                                                                                                Linear dynamic range
                                                                                                                                                                0.1 pg/mL to 50 ng/mL             0.001  0.000942  5.32     94.3
                                                                                                                                                                                                          0.00491
                                                                                                                                                                                                  0.005
                                                                                                                                                                                                                            98.9
                                                                                                                                                                                                                   3.54
                  in bioanalysis                                                                                                                                                                  0.01    0.00949  2.94     95.0
                                                                                                                                                                                                  0.05    0.0511   2.14     102.4
                                                                                                                                                                                                  0.1     0.0996   1.18     99.8
                  Bringing together ultra fast scanning technologies                                                                                                                              0.5     0.522    0.63     104.5
                                                                                                                                                                                                   1       1.01    0.26     100.8
                                                                                                                                                                                                   5       5.28    0.43     105.6
                  with high sensitivity pushes the limits of what we                                                                                                                               10      10.0    0.60     100.0
                                                                                                                                                                                                   50      48.8    0.33     97.8
                  can see.
                                                                                                                                      • Verapamil spiked into a plasma crash sample can be quantified at 100 ag on column with a precision of 5.08% for multiple injections (n=10).
                  The LCMS-8060 is built for high data quality and                                                                    • The LCMS-8060 also delivers a linear dynamic range from 0.1 pg/mL to 50 ng/mL.
                  drives confidence and consistency 24/7.
                                                                                                                                      High-Sensitivity Quantitation of Steroid Hormones
                                                                                                                                            300                                           1250
                                                                                                                                                LLOQ level of aldosterone                      Aldosterone 1 pg/mL
                                                                                                                                            250  (neat standard)                          1000  (neat standard)
                                                                                                                                            200
                                                                                                                                                   0.2 pg/mL               0.2 pg/mL      750          S/N 35
                                                                                                                                                   S/N 6.8                                             (peak to peak)      LCMS-8060
                                                                                                                                            150                            Blank
                                                                                                                                                   (peak to peak)                                                          LCMS-8050
                                                                                                                                                                                          500
                                                                                                                                            100                                                        S/N 9.5
                                                                                                                                                                                                       (peak to peak)
                                                                                                                                                                                          250
                                                                                                                                             50
                                                                                                                                             0                                              0
                                                                                                                                              2.0      2.5       3.0      3.5     min        2.0       2.5      3.0       3.5       min
                                                                                                                                                                                              Actual conc.  Mean area  RSD  Calc. conc.  Accuracy
                                                                                                                                                                                           Lv
                                                                                                                                                                                               (pg/mL)   (n=5)  (n=5, %)  (pg/mL)  (%)
                                                                                                                                           ×10 7                                           1    0.2      448      13.2    0.190    94.8
                                                                                                                                         6.00                                              2    0.5      1597     3.8     0.550    110.0

                                                                                                                                              0.2–20000 pg/mL
                                                                                                                                         5.00  Y=3187.32-156.16                            3     1       3225     2.5     1.06     106.1
                                                                                                                                               2
                                                                                                                                              R > 0.9992                                   4     2       6085     1.4     1.96     97.9
                                                                                                                                         4.00  16 levels                                   5     5      16398     2.0     5.19     103.9
                                                                                                                                         3.00                                              6     10     31448     1.1     9.92     99.2
                                                                                                                                                                                           7     20     63339     1.2     19.9     99.6
                                                                                                                                         2.00
                                                                                                                                                                                           8     50     158487    1.1     49.8     99.5
                                                                                                                                         1.00                                              9    100     322774    0.9     101      101.3
                                                                                                                                                                                           10   200     602459    0.3     189      94.5
                                                                                                                                         0.00                                              11   500     1556542   0.5     488      97.7
                                                                                                                                            0       5000     10000    15000    Conc
                                                                                                                                                                                           12   1000    3284586   2.1     1031     103.1
                                                                                                                                      • Aldosterone was detected at a lower concentration of 0.2 pg/mL   13  2000  5883876  0.5  1846  92.3
                                                                                                                                       using neat standards and the calibration curve was linear from 0.2   14  5000  15641489  0.3  4907  98.1
                                                                                                                                                                                           15  10000   31567190   1.0     9904     99.0
                                                                                                                                       to 20,000 pg/mL.
                                                                                                                                                                                           16  20000   59328173   2.6     18613    93.1


      8                                                                                                                                                                                                    Liquid Chromatograph Mass Spectrometer  LCMS-8060  9
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