Page 13 - Shimadzu LCMS-8060

High Sensitive and High Speed Forensic Screening

Ultra fast capabilities help to reshape workflows and help precise quantitation using the Synchronized Survey Scan ™ (SSS)
productivity by bringing together definitive quantitation and mode. This mode automatically performs product ion scanning once
information rich MS/MS spectra in a single analysis. a pre-defined threshold has been exceeded. Qual/Quan methods
The LCMS-8060 can quickly switch between a full scan analysis and can support a maximum of 1000 events in a single SSS methods.

Type Event# +/− Compound Name m/z Time (1.099 min - 6.690 min)
Expand your capabilities on Quan/Qual MRM 11 + + Flunitrazepam 314.05>268.15
Product Ion Scan
> 20.00 : 324.00
12
Quan/Qual approaches MRM 13 + + + Nimetazepam 296.05>250.20,
Product Ion Scan
> 20.00 : 306.00
14
15
MRM
Estazolam 295.05>267.15, 29
Product Ion Scan 16 + + > 20.00 : 305.00
Triazolam 343.05>308.20, 34
17
MRM
using ultra fast capabilities Product Ion Scan 18 + + > 20.00 : 353.00
MRM
19
Alprazolam 309.10>281.10, 3
Product Ion Scan 20 + > 20.00 : 319.00
Data acquisition method setting of Synchronized Survey Scan using MRM as survey and product ion scan as dependent event
Shimadzu is a global leader in ultra fast capabilities in mass
spectrometry creating methods that are designed to Quan/Qual method set up for the analysis of benzodiazepines in blood. The SSS method in rapid toxicology screening method package
combines MRM and MRM triggered product ion scanning for 161 compounds.
overcome real-world obstacles and deliver better data.
Inten. (×1,000,000)
5.0 Hit# Similarity Compound Name
1 89 Flunitrazepam_+_30V
2.5
0.0
50 100 150 200 250 300 m/z

Inten. (×1,000,000)
2.0 Hit# Similarity Compound Name
1.5 1 90 Flunitrazepam_+_30V
1.0
0.5
0.0
50 100 150 200 250 300 m/z

Inten. (×1,000,000)
4.0
Hit# Similarity Compound Name
3.0 1 90 Flunitrazepam_+_30V
2.0
1.0
0.0
50 100 150 200 250 300 m/z

Data acquisition method setting of synchronized survey scan using MRM as survey and product ion scan as dependent event

Blood samples were spiked with flunitrazepam at three points over a peak without loss of mass accuracy or quantitative
concentration levels (0.1, 1.0 and 10 ng/mL) and pretreated by a precision. In the case of the lower calibration standard at a
simplified QuEChERS method. Flunitrazepam was precisely detected concentration of 0.1 ng/mL the data quality of the product ion
at two different scan speeds 3,000 u/sec and 30,000 u/sec. At a spectrum was still maintained at 30,000 u/sec.
scan speed of 30,000 u/sec the LCMS-8060 acquires more data

12 Liquid Chromatograph Mass Spectrometer LCMS-8060 13