Page 18 - Shimadzu LCMS-8060

Compound Identification

LabSolutions Insight Library Screening Nexera UHPLC
™

LabSolutions Insight offers MS/MS library search capabilities. LabSolutions also enables you to produce high-quality results
Instrument parameters and MS/MS library spectra are available to without the need to define a threshold value to trigger a
Our unique approach to delivering high-quality,
deliver faster data acquisition, higher data quality, and enhanced spectrum, decreasing the chance of false negative reporting. This
identification. Shimadzu’s LabSolutions Insight software offers easy feature, MRM Spectrum Mode, acquires all compound fragments high-speed LC-MS/MS analysis is combining
viewing of the compounds of interest, including structural of interest in MRM mode and can be used to create accurate the Nexera UHPLC and LCMS-8060 as a
information, retention time and library similarity score. spectra from even trace concentrations.
seamlessly integrated system.

Analysis Cycle Time Less Than 10 Seconds

The SIL-40 autosampler can process the entire injection cycle time in as little as seven seconds, twice as fast as the previous model. In
addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically
increase analysis throughput.
Example of the screening of veterinary
drugs using MRM spectrum mode
6.7 sec
In MRM Spectrum Mode, known compound 22 h decrease
fragments are selectively acquired using multiple
MRM channels, enhancing signal for low abundance
analytes. Shimadzu's ultra-fast quadrupole technology
makes this a practical approach for large panels of
analytes.

0.00 0.25 0.50 0.75 1.00 1.25 min
LC/MS/MS Method Packages and MRM Libraries 8 injections can be completed within 1 minute (Caffeine) Nexera series Conventional LC

Shimadzu offers a wide variety Description Flyer code
of method packages Residual Pesticides C146-E306 Pharmacokinetic analysis requires not only speed but also high reliability at low concentrations. With its ultra-fast injection and ultra-low
Veterinary Drugs C146-E387
containing LC separation Water Quality Analysis C146-E180 carryover, the SIL-40 autosampler delivers high reproducibility and reliability, even during an ultra-fast 30-second analysis.
conditions and a number of Rapid Toxicology Screening C146-E224 Area
Primary Metabolites C146-E227 25000
predetermined MRM Lipid Mediators C146-E381 20000 Verapamil 40000
conditions. Laboratories can Method Packages Cell Culture Profiling C146-E279 455.1 > 165.1 30000
D/L Amino Acids C146-E336 15000 %RSD 4.4% (n = 50)
bypass time-consuming
Short Chain Fatty Acids C146-E355 10000 20000
method development steps Mycotoxins C146-E351
and realize results sooner. Forensic Toxicology Database C146-E344 5000 10000
Aminoglycoside Antibiotics C146-E352 0 R = 0.9997
2
Restricted Chemicals in Textiles C146-E382 0
Bile Acids C146-E386 0.00 0.25 min 0.0 2.5 5.0 7.5 10.0 12.5 15.0 17.5 Conc.
Metabolic Enzymes in Yeast C146-E275
MRM Libraries Verapamil in plasma (spiked 2.5 ppb) Linearity
Phospholipid Profiling C146-E314
Note: Check your local sales office to learn which packages are compatible
with each LCMS model.
Ultra-low Carryover
The Nexera boasts ultra-low carryover, even on a high-sensitivity LC-MS/MS. This reduces time spent on rinsing, resulting in a shorter
Traverse MS ™ overall analysis time.
Multivariate Analysis Software 3.0 (×10,000) (×1,000)
Traverse MS data analysis software enables mutivariate analysis of 2.5 3.0
Chlorhexidine 500 ng/ L
high complexity data in the field of metabolomics. Both Shimadzu 2.0 2.5
GCMS and LCMS MRM data can be analyzed to align, identify, 1.5 Blank 2.0
1.0 1.5 Carry over
and quantitate component peaks. Large sample sets can be 0.00007%
0.5 1.0
displayed graphically, statistical analysis can be performed, and
0.0 0.5
metabolite pathways can be mapped. 0.0 0.5 1.0 min
0.0
0.30 0.6 0.9 min
* Traverse MS is provided by Reifycs Inc.
After analysis of Chlorhexidine, the carryover to a blank solution is negligible. Rinse Conditions: Normal

18 Liquid Chromatograph Mass Spectrometer LCMS-8060 19