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Compound Identification


 LabSolutions Insight Library Screening  Nexera  UHPLC
                           ™

 LabSolutions Insight offers MS/MS library search capabilities.   LabSolutions also enables you to produce high-quality results
 Instrument parameters and MS/MS library spectra are available to   without the need to define a threshold value to trigger a
            Our unique approach to delivering high-quality,
 deliver faster data acquisition, higher data quality, and enhanced   spectrum, decreasing the chance of false negative reporting. This
 identification. Shimadzu’s LabSolutions Insight software offers easy   feature, MRM Spectrum Mode, acquires all compound fragments   high-speed LC-MS/MS analysis is combining
 viewing of the compounds of interest, including structural   of interest in MRM mode and can be used to create accurate   the Nexera UHPLC and LCMS-8060 as a
 information, retention time and library similarity score.   spectra from even trace concentrations.
            seamlessly integrated system.



            Analysis Cycle Time Less Than 10 Seconds

            The SIL-40 autosampler can process the entire injection cycle time in as little as seven seconds, twice as fast as the previous model. In
            addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically
            increase analysis throughput.
 Example of the screening of veterinary
 drugs using MRM spectrum mode
                                   6.7 sec
 In MRM Spectrum Mode, known compound                                    22 h decrease
 fragments are selectively acquired using multiple
 MRM channels, enhancing signal for low abundance
 analytes. Shimadzu's ultra-fast quadrupole technology
 makes this a practical approach for large panels of
 analytes.

                              0.00   0.25   0.50   0.75  1.00   1.25 min
 LC/MS/MS Method Packages and MRM Libraries  8 injections can be completed within 1 minute (Caffeine)  Nexera series  Conventional LC

 Shimadzu offers a wide variety   Description  Flyer code
 of method packages   Residual Pesticides  C146-E306  Pharmacokinetic analysis requires not only speed but also high reliability at low concentrations. With its ultra-fast injection and ultra-low
 Veterinary Drugs  C146-E387
 containing LC separation   Water Quality Analysis  C146-E180  carryover, the SIL-40 autosampler delivers high reproducibility and reliability, even during an ultra-fast 30-second analysis.
 conditions and a number of   Rapid Toxicology Screening  C146-E224  Area
 Primary Metabolites  C146-E227  25000
 predetermined MRM   Lipid Mediators  C146-E381  20000  Verapamil  40000
 conditions. Laboratories can   Method Packages  Cell Culture Profiling  C146-E279  455.1 > 165.1  30000
 D/L Amino Acids  C146-E336   15000         %RSD 4.4% (n = 50)
 bypass time-consuming
 Short Chain Fatty Acids  C146-E355  10000                      20000
 method development steps   Mycotoxins  C146-E351
 and realize results sooner.  Forensic Toxicology Database  C146-E344  5000  10000
 Aminoglycoside Antibiotics  C146-E352  0                                           R  = 0.9997
                                                                                     2
 Restricted Chemicals in Textiles  C146-E382                       0
 Bile Acids  C146-E386           0.00        0.25         min      0.0  2.5  5.0  7.5 10.0 12.5 15.0 17.5 Conc.
 Metabolic Enzymes in Yeast  C146-E275
 MRM Libraries                  Verapamil in plasma (spiked 2.5 ppb)         Linearity
 Phospholipid Profiling  C146-E314
 Note: Check your local sales office to learn which packages are compatible
 with each LCMS model.
            Ultra-low Carryover
            The Nexera boasts ultra-low carryover, even on a high-sensitivity LC-MS/MS. This reduces time spent on rinsing, resulting in a shorter
 Traverse MS ™  overall analysis time.
 Multivariate Analysis Software  3.0  (×10,000)                   (×1,000)
 Traverse MS data analysis software enables mutivariate analysis of   2.5  3.0
                                      Chlorhexidine 500 ng/ L
 high complexity data in the field of metabolomics. Both Shimadzu   2.0  2.5
 GCMS and LCMS MRM data can be analyzed to align, identify,   1.5  Blank  2.0
                             1.0                                1.5  Carry over
 and quantitate component peaks. Large sample sets can be            0.00007%
                             0.5                                1.0
 displayed graphically, statistical analysis can be performed, and
                             0.0                                0.5
 metabolite pathways can be mapped.  0.0  0.5     1.0       min
                                                                0.0
                                                                 0.30        0.6        0.9  min
 * Traverse MS is provided by Reifycs Inc.
                             After analysis of Chlorhexidine, the carryover to a blank solution is negligible.  Rinse Conditions: Normal

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