Page 4 - Shimadzu LCMS-8060
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LCMS-8060

            Triple Quadrupole Mass Spectrometer



            Pushes the limits of what we can see

                                                                                                                                                      Fenoxaprop-ethyl              Clofentezine                 Triclopyr
                                                                                                                                                 ×10 6                       ×10 5                     1.5    ×10 5
                                                                                                                                                 Positive                 7.5    Positive                 Negative
                                                                                                                                              4.0   m/z 362.15>288.20         m/z 303.1>138.05            m/z   254.0>196.0
                                    Sensitivity           Speed             Solutions                                                                         LCMS-8060   5.0             LCMS-8060    1.0            LCMS-8060
                                                                                                                                                                                          S:×4.2
                                                                                                                                                                                                                      S:×3.3
                                                                                                                                                              S:×4.4
                                                                                                                                              2.0
                                                                                                                                                                          2.5                          0.5
                                                                                                                                                                                          LCMS-8050                   LCMS-8050
                                                                                                                                                              LCMS-8050
                                                                                                                                              0.0                         0.0                          0.0
            The LCMS-8060 is a ground breaking innovation in mass spectrometry helping to transform LC/MS/MS data quality by developing a new       10.0   10.5   11.0   min     9.5    10.0   10.5  min     5.5    6.0    6.5   min
            vision of sensitivity and speed.
                                                                                                                                                 ×10 4                      ×10 4                        ×10 3
                                                                                                                                                                                                       1.0
                                                                                                                                              2.5
            Shimadzu is the first mass spectrometry company in the world to deliver a triple quadrupole mass spectrometer with the highest                                1.0                          0.5
            sensitivity and ultra-fast technologies to create an innovation that really matters.                                              0.0                         0.0                          0.0
                                                                                                                                                    10.0   10.5    11.0   min    9.5    10.0   10.5  min     5.5    6.0    6.5  min
                                                                                                                                                    MRM chromatograms: 100 ng/mL neat standard, upper: signal comparison, lower: baseline noise comparison
                                              By redefining the ion focusing capability on the UF-Qarray , the LCMS-8060 brings a
                                                                                        ™
             Sensitivity                      meaningful impact to quantitative detection and opens new opportunities for scientists to
                                              deliver solutions that make a true difference.                                          Built on the proven platform of the LCMS-8050, the new patented   sensitivity compared to previous technologies. The chromatogram
                                                                                                                                      ion guides developed for the LCMS-8060 greatly improves ion   for each pesticide has been magnified to show the noise has not
                                              The newly developed UF-Qarray ion guide is a groundbreaking technology that increases   production and collisional focusing without affecting noise.   increased with a higher ion production. Innovations in ion guide
                                              LC/MS/MS sensitivity by enhancing ion signal intensity and reducing noise. By improving   The ion production, transmission and detection of three pesticides   technologies not only delivers new limits of MRM sensitivity but
                                              the ion sampling device, the ion guide, and the vacuum efficiency, the LCMS-8060 delivers   (fenoxaprop-ethyl, clofentezine and triclopyr) results in increased   has an impact on full-scan sensitivity.
                                              a new vision of sensitivity and makes a real difference to working better and faster.
                                    Heated ESI
                                    Probe

                                                                                                                                                                                             Inten. (×10,000)
                                                                                                                                                                                                                  LCMS-8060
                                                                                                                                                                               8.5–12.5 min    3.00   520.4       LCMS-8050
                                      Drying Gas                                                                                                                                           2.50
                                                                                                                                                                                                  LCMS-8060
                                                                                                                                                                                           2.00
                                                                                                                                                                                           1.50
                                                                                                                                                                                           1.00
                   Heating Gas                                                                                                                     1.5 × 10    7                           0.50
                                  DL (Desolvation Line)                                                                                                                                    0.00
                                                                                                                                                                                           3.00
                                                           UF-Qarray                  UF-Lens ™                                                                                            2.50
                                                                                                                                                                                                  LCMS-8050
                                                                                                                                                                                           2.00
                                                                                                                                                   1.0 × 10 7
                                                                                                                                                                                           1.50
                                                                                                                                                                                           1.00
                                                                                                                                                                                           0.50   520.5
                                                                                                                                                   0.5 × 10 7                              0.00
                                                                                                                                                                                                500   750   m/z

                                                                                                                                                      0
                                                                                                                                                       8.0   9.0   10.0  11.0  12.0  13.0  14.0  15.0  16.0  17.0  18.0  min
                                                                                                                                                         Comparison between the LCMS-8060 (purple) and LCMS-8050 (blue) for the analysis of lipids
                                                                                                                                                           (precursor ion scanning at m/z 184-choline-containing phospholipids in positive ion mode)

                                                                                                                                      Lipid profiling on the LCMS-8060 can detect more ion signals with   LCMS-8060 systems using a scan speed of 3,000 u/sec. With the
                                                                                                                                      greater precision and with higher confidence. After protein   LCMS-8060 lower levels of phosphatidylcholine could be detected
                                                                                                                                      precipitation, the human serum sample was diluted 1000 times by   in a human serum sample following a protein crash sample
                                                                                                                                      methanol and 1µL was injected onto the LCMS-8050 and   preparation compared to the LCMS-8050.



      4                                                                                                                                                                                                    Liquid Chromatograph Mass Spectrometer  LCMS-8060  5
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