Page 22 - Application Handbook - TOC

SCA-130-202

For users who prefer wet-chemical oxidation
for the determination of TOC, the TOC-V WP
analyzer with its various options, is available.
The key technique of the TOC-V WP analyzer
is the powerful oxidation via the combination
of sodium persulfate and UV oxidation at
80°C.

Practical Example:
■ Instrument / Measurement parameter
The TOC-L CPH employs the proven catalytic Unit: TOC-L CPH
oxidation at 680 °C. The integrated sample Catalyst: High sensitivity catalyst
preparation (ISP) module greatly reduces the Meas.-typ: NPOC
users’ workload, as the instrument Cal-Curve: 2-Punkt Calibration Curve
0-3 mgC/L (KHP)
automatically carries out the dilution, Injection vol.: 500 μL
acidification and degassing steps.
■ Results
TOC-
Compound Recovery
Result
Blank 0,030mg/L
Tranexamic acid 2,14mg/L 105 %
Anhydrous caffeine 2,19mg/L 108 %
Isopropylantipyrine 2,20mg/L 109 %
Nifedipine 2,17mg/L 107 %
Gentashin ointment 0,117mg/L 4,35 %
Rinderon ointment 0,333mg/L 15,2 %

From the results, it can be concluded that the
final rinse method only shows good
recoveries for water-soluble compounds.

(Further information is available in the
application note Japan TOC O41)

Fig. ISP-Module of TOC-L series

The possibility for simultaneous determination
of the TNb (total nitrogen) using the TNM-L
module enables, if necessary, a
differentiation between cleaning agent and
product. This may be of great importance,
particularly for biopharmaceutical products.