Page 39 - Pharmaceutical Solution for Pharma Analysis

Application No.T152
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Q Measurement of Tripalmitin DSC
mW
Tripalmitin is also known to be polymorphic. In Fig. 4,
the melting peak seen at 61.6 ˚C during the first run 1st run
corresponds to melting of stable crystal form Ќ. 5.00 42.5 ˚C
Next, an exothermic peak at 42.5 ˚C is seen during the heat of fusion: -183.6 J/g
cooling process. This peak equates to crystallization of heat of fusion: 122.3 J/g
quasi-stable crystal form Ћ. The exothermic/ 61.6 ˚C
endothermic peak observed in the region of 45 ˚C to 0.00 Cooling
58 ˚C during the second run equates to melting of
form Ћ followed by crystallization of form Ќ. The 2nd run heat of fusion: -44.0 J/g
heat of fusion of form Ќ melting at around 60 ˚C is -5.00 heat of fusion: -115.4 J/g 60.7 ˚C
observed to be smaller due to incomplete crystallization
of form Ќ. 46.5 ˚C
30.0 40.0 50.0 60.0 70.0 80.0
Temp [˚C]
Fig. 4 DSC Measurement of Tripalmitin

Q Measurement of a Suppository DSC
mW
Fig. 5 shows data from heating (first run), cooling, and
reheating (second run) of a commercially available 1st run ˠ heat of fusion: -111.4 J/g
suppository drug. The melting peak shapes are different 20.00 22.3 ˚C
during the first run and second run. This difference is 28.4 ˚C
due to a change in the crystal form of triglyceride
present in the suppository drug caused by the heating 10.00 14.8 ˚C 35.0 ˚C
method used. Because different crystal forms give rise 19.6 ˚C ˡ Cooling
to different melting characteristics and cracking heat of fusion: 75.8 J/g
behaviors, optimum heat treatment conditions must be 0.00
investigated. 2nd run ˠ heat of fusion: -75.8 J/g

-10.00 33.6 ˚C
-20.00 0.00 20.00 40.00 60.00
Temp [˚C]
Fig. 5 DSC Measurement of a Suppository
Q Measurement of Sulfathiazole DSC
mW
Fig. 6 shows the results of analyzing sulfathiazole. The 6.00
peak at 169.8 ˚C is presumed to represent the transition 3.00
from a quasi-stable phase to a stable phase, and the heat of fusion: -26.8 J/g heat of fusion: -107.0 J/g
peak at 201.1 ˚C is presumed to be melting of the 0.00
stable phase. 169.8 ˚C
-3.00
-6.00
-9.00
-12.00
201.1 ˚C
-15.00
100.00 150.00 200.00
Temp [˚C]
Fig. 6 DSC Measurement of Sulfathiazole

First Edition: Jan. 2017

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