Page 59 - Clinical-Medical Solution for Clinical Chemistry

A Novel Platform of On-line Sample Pre-treatment and LC/MS/MS
Analysis for Screening and Quantitation of Illicit Drugs in Urine

Table 2: MRM transitions and parameters of the illicit drugs on LCMS-8060
Standard Internal Standard
Compd. R.T (min) MRM (m/z) CE (V) Compd. R.T (min) MRM (m/z) CE (V)
296.1>250.2 -26 287.2>241.2 -26
Nimetazepam D5-Nitrazepam
6.053 296.1>221.2 -34 5.63 287.2>185.2 -36
(NIME) (D5-NITRA)
296.1>165.2 -57 287.2>212.2 -34
238.1>125.2 -28 242.2>129.1 -27
Ketamine
4.334 238.1>220.2 -16 D4-KET 4.32 242.2>224.2 -15
(KET)
238.1>207.2 -14 242.2>211.2 -15
224.1>125.2 -24 228.1>129.1 -25
Norketamine
4.105 224.1>207.2 -13 D4-NORKET 4.09 228.1>211.2 -12
(NORKET)
224.1>179.2 -15 228.1>183.2 -16
468.3>55.2 -60 472.3>59.2 -54
Buprenorphine
5.019 468.3>414.4 -36 D4-BU 5.01 472.3>400.3 -40
(BU)
468.3>396.3 -41 472.3>101.1 -43
414.2>83.2 -52 417.3>83.2 -50
Norbuprenorphine
(NORBU) 4.622 414.2>101.1 -44 D3-NORBU 4.61 417.3>101.2 -41
414.2>187.2 -38 417.3>187.2 -41
286.1>200.9 -26 289.1>157.1 -43
Morphine
(MORP) 2.663 286.1>151.9 -61 D3-MORP 2.66 289.1>165.1 -41
286.1>164.9 -41 289.1>153.1 -41
300.1>164.9 -45 303.1>151.8 -67
Codeine
(COD) 3.474 300.1>214.9 -27 D3-COD 3.46 303.1>164.9 -45
300.1>151.8 -65 303.1>214.9 -27
328.1>164.9 -39 334.1>164.9 -40
6-MAM 3.475 328.1>210.9 -26 D6-MAM 3.46 334.1>210.9 -27
328.1>192.9 -29 334.1>192.9 -30
290.2>168.2 -20 293.2>171.3 -20
Benzoylecgonine
4.260 290.2>105.1 -31 D3-BE 4.25 293.2>105.1 -29
(BE)
290.2>77.1 -53 293.2>77.1 -55
244.3>86.2 -12
Phencyclidine
5.204 244.3>159.3 -14 N.A.
(PCP)
244.3>91.2 -30
251.2>132.2 -27
Methaqualone
5.786 251.2>91.2 -45 N.A.
(METQ)
251.2>65.2 -61
310.2>265.3 -17
Methadone 5.632 N.A.
(METD) 310.2>105.1 -27
310.2>77.1 -53
Propoxyphene 340.2>58.2 -23
(PROP) 5.220 340.2>266.3 -10 N.A.
136.3>91.5 -21 141.3>124.3 -19
Amphetamine
(AMPH) 3.111 136.3>119.1 -14 D5-AMPH 3.066 141.3>92.2 -14
136.3>65.0 -37 141.3>93.2 -17
208.3>163.2 -14 214.3>166.2 -13
MDEA 3.919 208.3>105.2 -27 D6-MDEA 3.906 214.3>136.2 -20
208.3>135.1 -22 214.3>108.2 -26
180.3>163.2 -12 185.3>168.3 -12
MDA 3.440 180.3>135.2 -19 D5-MDA 3.424 185.3>110.3 -23
180.3>79.2 -32 185.3>138.3 -20
194.2>163.3 -14 199.3>165.3 -13
MDMA 3.678 194.2>105.2 -24 D5-MDMA 3.664 199.3>107.2 -26
194.2>133.2 -21 199.3>135.2 -20
150.3>91.2 -21 158.3>93.2 -21
Methamphetamine
3.430 150.3>119.2 -15 D8-METH 3.403 158.3>124.3 -15
(METH)
150.3>65.1 -43 158.3>92.2 -19
5