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Gas Chromatograph (GC)  Gas Chromatograph (GC)






 Solvent Residue                1            5                             8
                                                             7
 Residual solvents in pharmaceuticals are defined as volatile organic compounds used in or generated from the manufacture of drug   1:Hexane
 substances, pharmaceutical additives, or drug products. They are strictly controlled according to risk classifications from Class 1 to Class 3,   2:Nitromethane
 which are based on the risk to human health.                                         3:Chloroform
 Headspace GC methods specified in the USP (U.S. Pharmacopeia), General Chapters <467> Residual Solvents, are commonly used for   4:1,2-Dimethoxyethane
 analysis of residual solvents.Presented here is an analysis of residual solvents as described in USP<467> carried out with an HS-20   5:Trichloroethene
                                                                                      6:Pyridine
 headspace sampler and a Shimadzu Nexis GC-2030 Gas Chromatograph.  3                 7:Methylbutylketone
                                                                                      8:Tetraline
 Analytical Conditions                                  6
 Instrument   :Nexis GC-2030   Headspace sampler :HS-20  2
 Detector  :FID-2030  Vial equilibration  :60 min @ 80°C   4
 Column   :SH-Rxi-624 Sil MS (0.32 mm I.D. × 30 m, d.f. = 1.8 µm)  Sample line temp  :110°C
 Carrier gas   :Helium, 99.9995% purity  Transfer line temp  :120°C
 Injection volume   :1 mL  Vial pressurization  :1.00 min @ 75 kPa   5.0   10.0   15.0   20.0   25.0  30.0  35.0  min
 Linear velocity   :35 cm/s (constant linear velocity)   Loading time   :1 min
 Injection mode   :Split 1:5  Chromatogram of WATER-SOLUBLE ARTICLES Class 2B Standard Solution by Procedure A
 Column temperature  :40 °C (20 min) - 10 °C /min - 240 °C (20 min) Total 60 min
 Detector temperature :250ºC
            Shimadzu Gas Chromatograph Product Lineup


 S/N ratio and Repeatability of Class1  Model                          Features
                                      · Ideal for routine analysis in the R&D lab or industrial setting
 No.  Compounds  S/N ratio  %RSD (n=6)  · Wide range of applications from capillary to packed column analysis
                                      · Large GC oven accommodates up to 4 detectors and 2 injection ports
 1  1,1-Dichloroethane  320  2.8      · With 7 heated zones and sixteen 24 volt relays, a perfect platform for our System GC program
 2  1,1,1-Trichloroethane  220  2.3
 3  Carbon tetrachloride  20  2.9
                   GC-2014
 4  Benzene  170  2.5
 5  1,2-Dichloroethane  60  3.4       · Flagship model
                                      · Touch-panel interface, which features clear graphics that display information instantly whenever needed.
                                      · High-sensitivity detectors support a wide variety of analyses
                                      · Intelligent flow controller with exceptional reproducibility
                                      · Advanced flow technology ensures seamless method transfer to GCMS
                                      · Faster analysis with hydrogen carrier gas
                                      · “Eco mode” to optimize the use of carrier gas such as helium and reduce electricity use when idle.
                                      · Equipped with day and time programming, system self-check feature, automatic notification of when to
                Nexis GC-2030           replace consumables.
                                      · A choice of four inlets, six detectors, and specialized valve accessories enables configurations tailored to
                                        fit the needs of laboratories.










 Nexis GC-2030 + HS-20






                                          Solutions for Palm Oil Analysis Application Notebook
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