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Analysis of Residual Pesticides Analysis of Veterinary Pharmaceuticals

Gas Chromatograph (GC) Liquid Chromatograph (LC) Veterinary pharmaceuticals are used in the diagnosis, cure, mitigation, treatment, and prevention of diseases in animals as
well as in the promotion of growth. However, there is increasing concern about these drugs entering the food chain and their
Capillary GC can be utilized for the analysis of residual GC or GC-MS techniques may not be suitable for analysis of
pesticides in foods. Using a selective detector such as FPD, residual pesticides that thermally decompose or have a effects on the human body. These drugs are categorized in many classes, such as anabolic hormones, anthelmintics,
FTD or ECD offers highly sensitive analysis of trace pesticides. highly polar chemical structure. In contrast, an HPLC antibiotics, beta-agonists, coccidiostats, corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and sedatives. Below
equipped with a photodiode array detector can acquire are a few examples of veterinary pharmaceutical analyses.
reliable chromatograms with spectral information for
methamidophos chlorpyrifos-methyl + dimethoate (E)-dimethylvinphos fenthion (Z)-dimethylvinphos (Z)-chlorfenvinphos fosthiazate 2 + prothiofos building libraries to compare compounds. The Shimadzu Analysis of Multiple Veterinary Pharmaceuticals in Pork (LC-MS/MS)
carbamate analysis system incorporates derivatization

dichlorvos acephate thiometon salithion terbufos diazinon etrimfos iprobenfos dichlofenthion cyanophos tolclofos-methyl pirimiphos-methyl formothion malathion fenitrothion (MEP) isophenphos + quinalphos phenthoate profenofos + methidathion ethion + sulprofos pyridaphenthion technologies to achieve high-sensitivity, selective analysis of Veterinary pharmaceuticals are often used to promote the growth of farm animals, but many of these compounds are subject
N-methyl carbamate pesticides.
to residue standards. From this background, there is a need for a highly sensitive and rapid analytical technique to analyze as
cadusafos ethoprophos phorate chlorpyrifos (E)-chlorfenvinphos fosthiazate propaphos butamifos edifenphos fensulfothion cyanofenphos EPN phosmet phosalone pyraclofos 60 mV many of these compounds as possible in a single run. LC-MS/MS enables simultaneous analysis of multiple veterinary
pharmaceuticals with high sensitivity.
50 Oxamyl Methomyl Methiocarb sulfoxide Aldicarb
Pesticide-spiked meat dumpling sample (0.2 µ g/g equivalent) Methiocarb sulfone Carbaryl Triple Quadrupole Mass Spectrometer
40 Ethiofencarb
Normal meat dumpling sample Bendiocarb Fenobucarb LCMS-8060
30 Methiocarb
Chromatograms of Normal Meat Sample and Pesticides-spiked Meat Sample
20
Gas Chromatograph Nexis GC-2030 10
0
0.0 5.0 10.0 15.0 20.0 25.0 min
Chromatogram of a Standard Mixture of 10 N-Methylcarbamate Pesticides
MRM Chromatograms of 89 Veterinary Pharmaceuticals in Pork
High-Performance Liquid Chromatograph Source: Shimadzu Application News No. C99
Prominence Series
Carbamates Pesticides Analysis System
Analysis of Veterinary Pharmaceuticals Using MRM Spectrum Mode (LC-MS/MS)
MRM Spectrum Mode was developed to reduce false positives and false negatives in analysis of veterinary pharmaceuticals.
MRM Spectrum Mode acquires a high number of fragment ion transitions for each target compound and generates
fragmentation spectra. In examination of quantifying and identifying 212 veterinary pharmaceuticals, the level of confidence
in compound identification and verification increased in MRM Spectrum Mode, and limits of detection, linearity or
Features
repeatability were not compromised compared to a conventional method (2 MRM / compound).
Easy Operation
An advanced interface enables intuitive operation with clear
graphics. Shimadzu's latest tool-free maintenance technology makes
daily maintenance easy.
High Sensitivity and Reproducibility Features
Achieves high sensitivity with all of the detectors, such as FID and Rapid Injection
BID. The advanced flow controller (AFC) enhances reliability with An injection time of 10 seconds for a 10 µL sample enhances analysis
excellent repeatability. efficiency.
Exceptional Expandability and Productivity High Sensitivity and Linearity over a Broad Range
Nexis GC-2030 can be customized to meet customers' specific Upgraded optical and electrical systems reduce noise for lower
requirements and needs. Options and functions to use hydrogen detection limits and ensure simultaneous analysis of major
carrier gas safely in high-speed analysis maximize analysis components and trace components.
productivity. Low Sample Carryover
Platinum coating minimizes the adsorption of sample components
on to the needle surface. MRM Spectra and Calibration Curve of Sulfamerazine (1 pg/µL to 100 pg/µL)
Source: Shimadzu Application News No. C161

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