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Drug Discovery

Conclusion and future

During our investigation, we observed that mouse microsomes
degrade compounds more quickly than human microsomes. We are
currently in process to characterize these metabolites in order to guide
the synthesis of new analogs for the research group of Prof. Cook. We
will expand this method to pharmacokinetic studies in the near future.

Acknowledgements

Financial support: National Institute of Neurological Disorders and
Stroke, National Institute of Mental Health, National Heart, Lung and
Blood Institute, University of Wisconsin Milwaukee, UWM Research
Foundation, UWM Department of Chemistry and Biochemistry, and
UWM Graduate School.

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