Page 9 - Shimadzu LCMS-8050

UFscanning

UFsensitivity

UFswitching
UF-MRM

Only 5 msec to Achieve Stable Ion intensity is maintained even
Quantitative Accuracy with when performing polarity switching at ultra-high speed.
Positive/Negative Ionization Switching
100 609.20>195.20 (+) 100 100
The LCMS-8050 uses unique high-voltage power supply technology 138.00>108.10 (–)
to achieve an ultra-high-speed positive/negative ionization switching % % %
time of just 5 msec. The LCMS-8050 is also the only instrument of its
type to maintain ion intensity even when performing polarity
0 0 0
switching at ultra-high speed, yielding consistent, reproducible data.
0.0 0.1 0.2 min 0.0 0.1 0.2 min 0.0 0.1 0.2 min
Excellent quantitative results can be obtained from UHPLC peaks no
more than 2-3 seconds wide, even when multiple components are Positive Positive Negative
eluted simultaneously. Negative
Comparison of measurement using the ultra-fast polarity switching
(5msec) and individual measurement of positive and negative ions.

Outstanding Throughput and Quantitative Accuracy

Analysis Start Analysis End
Positive and negative + -
ions measured separately
Analysis Time: 2 min Analysis Time: 2 min
After completing an analysis in positive ion mode,
a second analysis begins in negative ion mode.

Inadequate polarity Switching -
switching + Switching - Switching + Switching
Cycle time 3 4 Analysis Time: 2 min Since the cycle time is longer, sufficient data points
cannot be obtained for each peak.
Loss of quantitative accuracy
5
2
1 6
Ultra-fast polarity + - + -
switching
6 A short cycle time enables acquisition of a sufficient
Cycle 5 7 Analysis Time: 2 min
time number of data points for each peak.
4 8
Maintains quantitative accuracy
3 9
1 2 10 11

Liquid Chromatograph Mass Spectrometer /&06 9