Page 14 - Shimadzu LCMS-8050

Engineered for Robustness and Easy Operation/Maintenance

Maintains High Sensitivity Even During Successive Demanding Analyses
In addition to speed and sensitivity, Shimadzu designed the LCMS-8050 for robustness to meet the most demanding laboratory requirements
and most difficult matrices. The figure below plots the area results from 1000 consecutive analyses of a deproteinized blood plasma sample
spiked with alprazolam. The LCMS-8050 achieves excellent reproducibility with a 4.59 % RSD for the area results over the 1000 analyses.

×10 4
40
50 pg/mL alprazolam in plasma
m/z 309.05 > 281.15
30 Area % RSD = 4.59 %

Area 20
(×10 3 ) (×10 3 ) (×10 3 )
1 st 500 th 1000 th
injection injection injection
10 5.0 5.0 5.0

0.0 0.0 0.0
1.0 1.1 1.2 1.3 1.4 min 1.0 1.1 1.2 1.3 1.4 min 1.0 1.1 1.2 1.3 1.4 min
0
0 100 200 300 400 500 600 700 800 900 1000
Injection

Easy System Maintenance Reduces Downtime

As with Shimadzu’s other triple quad systems, maintaining the LCMS-8050 is simple. Replacing the desolvation line (DL) and ESI capillary is
quick and easy. Additionally, the design allows users to replace the DL without breaking vacuum, providing greater uptime and usability.

Steps for DL Replacement

2

1

3
DL (Desolvation Line)

Steps for ESI Capillary Replacement

3
1
2

ESI Capillary

14