Page 6 - Shimadzu Nexera X2

Higher Sensitivity and Resolution Than Ever Before

Nexera SR System
N e x
Th e SP
The SPD-M30A photodiode array detector included in Nexera SR systems has been completely
redesigned from previous models and features uncompromised improvements throughout the
redesi
ign
d
design, from the cell structure to the temperature control method. This not only increases the
es
sensitivity of UHPLC systems, but also improves the sensitivity and separation of HPLC systems,
sensit
making it suitable for the flagship model of the Nexera X2 series.
makin

Detector Cell Offers Both Sensitivity and Resolution

While the SR-Cell (sensitivity and resolution cell) used in the mV About 2.3 times : Standard SPD-M30A cell
150 higher S/N ratio : Standard SPD-M20A cell
SPD-M30A has an optical path length of 10 mm, it features
low-dispersion specifications compared with previous models.
It achieves sharper peaks in UHPLC analysis while remaining just 100
as easy to use for HPLC as before, and can be used for a wide
range of applications from UHPLC to HPLC.
50
About 1.5 times
Analytical Conditions
higher S/N ratio
Flow rate 1.0 mL/min
Column Shim-pack XR-ODS II (75 mmL. × 2.0 mmI.D., 2.2µm) 0.0 1.0 2.0 3.0 4.0 5.0 6.0 7.0 min

Even Higher Sensitivity with an Optional Cell

While the optional high-sensitivity cell features an optical path mV
length of 85 mm, the noise level is kept to a minimum. 120 : High-sensitivity SPD-M30A cell
: Standard SPD-M30A cell
The improved S/N ratio enables analysis of trace impurities and 110
trace components, which was not possible before. 100
90 Impurity 2
Analytical Conditions 80
70 Impurity 1
A) 20 mmol/L phosphate buffer solution with pH 2.8 Impurity 4
Mobile Phase 60
B) Acetonitrile
50 Impurity 3
Column Shim-pack XR-ODS II (150 mmL. × 3.0 mmI.D.) 40 Impurity 5
Sample Cefazolin sodium 30
20
10
Comparison of Signal Strength
0
High-Sensitivity Cell Standard Cell
1.00 1.50 2.00 2.50 min
Impurity 1 49109 7931
Impurity 2 81339 11438
Impurity 3 16345 2290
Impurity 4 37922 5548
Impurity 5 7726 968

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