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Quickest Way to Results







                     Automates Development of Analytical Conditions                                                                     Unique Functionality Reduces Data Analysis Work

                     Method Scouting                                                                                                    i-PeakFinder ™

                     The process of considering which analytical conditions to specify for LC separation requires evaluating a huge number of   The process of identifying peaks obscured by baseline undulations or noise, identifying shoulder peaks with inade-
                     possible combinations of columns, mobile phases, column temperatures, and other factors, which can be taxing on    quate separation, and so on, can be very tedious and produce results that vary depending on skill level. Shimadzu's
                     analytical personnel. The Nexera method scouting system offers functionality for automatically switching between multiple   unique i-PeakFinder peak integration algorithm is perfect for accurately detecting peaks in troublesome chromatograms.
                     mobile phase conditions and columns for analysis. Consequently, it can be used to develop methods more efficiently by
                     automating the process of optimizing mobile phase pH, salt concentration, or other analytical condition settings.
                                                                                                                                                      Baseline Processing = No Setting       Baseline Processing = Vertical Division



                     Previous Method                                                                                                                   Aggregate  Monomer  Fragments             Aggregate  Monomer  Fragments

                         Create method  Create schedule         Acquire data                  Analyze data

                      A method must be created for each combination of
                      column and mobile phase. Creating this large number
                      of methods is labor-intensive.
                                                                                     The operation is complicated because a large
                                                                                     amount of data is manually combined into
                                                                     Column 4
                                                      Column 1
                                                                             Column 5
                                                                                 Column 6
                                                         Column 2
                                                                  Column 3
                                                                                     one report.                                                   12.0     14.0      16.0    min           12.0      14.0      16.0   min
                                                              Overnight
                                                                         Overnight
                     Method Scouting System + LabSolutions MD
                      Set conditions  Create schedule  Acquire data   Analyze data
                                 automatically
                      Methods are automatically created                                                                                 Carefully Selected Functionality for Supporting Data Analysis
                      with different combinations of
                      columns, mobile phases, etc.
                                                                                                                                                             ™
                                                                Templates are output  Print out                                         LabSolutions Insight  Software for LC/MS Data Analysis
                                                                 after being auto-  as a 1-page
                                                       Column 4
                                                             Column 6
                                                          Column 5
                                                    Column 3
                                                Column 2
                                             Column 1
                                                                 matically filled with  report.
                                                                 analytical results.                                                    This dedicated LC/MS analysis software features functionality that provides powerful support for multiple-component
                                                                                                                                        and multi-sample data analysis, such as functionality for flagging, filtering, and peak comparison.
                                                                     mAU
                                                                     2
                                                                                                        pH 5.7
                                                                     0
                      85%                  A
                                                                     2
                                      10%  B                                                            pH 6.0
                                                       X
                                       5%  C                         0
                                                                     2
                                        0% D         Solvent                                            pH 6.3
                                                    delivery unit 1
                                                                     0
                             50%
                                           A                   Mixer  2
                                   20%                                                                  pH 6.6
                                           B
                                                       Y             0
                                       5%  C
                                                                     2
                                  25%      D         Solvent                                            pH 6.9
                                                    delivery unit 2
                                                                     0
                             Solvent Blending      Binary Gradient   2
                                                                                                        pH 7.2
                         Mobile phases prepared   Gradient analysis   0
                         automatically at each pump  with mobile phases  0.0   2.5       5.0      7.5       min
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