Page 6 - Shimadzu Nexera Prep

Preparative Work for Target Components at

High Purity Levels and High Concentrations

Equipped with Technology for the Trap Enrichment of Target Components
Nexera UFPLC, Ultra Fast Preparative and Purification

Liquid Chromatograph System

Significantly Reduces the Processes involved from Separation to Purification
(Free-basing Treatment) and Powderization

The ultra fast preparative and purification liquid chromatograph system, Nexera UFPLC, streamlines purification operations by
automating the preparative process from separation to concentration, purification, and collection.
In conventional preparative LC, the amount of fraction is diluted with the mobile phase, resulting in a huge volume, which takes
time to evaporate, and post-treatment work, such as removal of salts derived from the mobile phase, is required.
Nexera UFPLC concentrates target components by using a trap column. In addition, salts derived from the mobile phase and
counter ions of the target compound are removed. Furthermore, because organic solvents are used to elute the target components,
the time for evaporation can be significantly reduced.
Nexera UFPLC can also be used for standard preparative chromatography by collecting the fractions directly without any concen-
tration steps.
Isolates fraction containing target peaks
and concentrates it in a trap column

Removes impurities
and pair ions

Elutes components
using organic solvent
Target
compounds
Pair ion Fractionation/
(ex TFA)
concentration
Sample containing
target components Purification

Elution

Recovery of target
compounds in
high-purity liquid

6