Page 4 - Shimadzu Nexera Prep

Streamline and Simplify Establishing the

Conditions for Preparative Work

Fully Equipped with Functions to Reliably Prepare Target Components
Nexera Prep System

Streamline development of Analysis Conditions and Optimization of
Preparative Parameters

In order to separate multiple components, the analysis and fractionation parameters must be optimized, which involves a great
deal of work.
Shimadzu provides the Method Scouting system, which investigates conditions at the analytical level. Method Scouting
system fully automates method scouting in which combinations of mobile phases and columns are automatically changed,
equilibrated, and evaluated, allowing efficient method development.
Further, the preparative system performs automatic simulations using the pre-preparative results, enabling optimiza-
tion of the fractionation parameters.
This reduces the work involved in investigating conditions, which saves on mobile phase solvent and samples.

Development of Analytical Conditions (Method Scouting System)

Column A development is performed to separate the target
compounds at the analysis level.
Solvent Delivery
Unit Using the Shimadzu Method Scouting system
Flow Line Switching Unit Detector
(Built into the solvent delivery unit)
together with Method Scouting Solution, a special
Autosampler
software program, provides a fast and accurate
method scouting workflow, which supports height-
Analysis
Solvent Delivery Flow Line Selection Valves
Unit ened efficiency in method development.
Flow Line Switching Unit Column Oven
(Built into the solvent delivery unit)
Significantly Reduces the Process of Setting Fractionation Parameters
Simple parameter setting by fraction simulator
™
LabSolutions software provides simulation functions that reduce the labor involved in investigating conditions
for analytical and preparative work.
With the LabSolutions fractionation simulator (patent pending), specify the peak segment in the chromato-
gram to fractionate, and the system automatically sets the parameters required for fractionation. This reduces
the time spent on setting fractionation conditions to about 1/4 the typical expenditure.

Noise skipping by new algorithm
Prep arative
When configuring fractionation via automatic peak recognition, noise in the chromatogram is sometimes
mistaken for component peaks, resulting in an insufficient number of test tubes for intended collection or
improper positioning of collected fractions. With the LabSolutions software Peak Sensitivity Determination
function (patent pending), peaks are recognized from the number of data points consecutively exceeding the
configured threshold value, to determine whether to fractionate.

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1 1 2 1 2 5
Level

Conventionally,noise can erroneously cause collection With the Peak Sensitivity Determination function, noise is distinguished
from the component peaks (Peak Sensitivity Setting: 5)

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