Page 7 - Shimadzu LCMS-IT-TOF
P. 7
Ion fragmentation is very useful in structural analysis. The LCMS-IT- R
TOF has a unique design in that it connects an ion trap with a TOF
n
and provides high-precision mass information for either MS or MS .
N
This makes it possible to perform highly reliable structural analysis.
H3C S
N
O O
R
C19H21O3N3S
MS 1 [M+H] +
Expected 372.1376
372.1365
-2.96 ppm
50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 m/z
MS 2 [372--SO2Me] +
-78.9854 Da
Expected 293.1523
(Expected 78.9854)
293.1511 0.0 mDa
-4.09 ppm
50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 m/z
MS 3 [293--C2H3O] +
-43.0180 Da
Expected 250.1339
250.1331 (Expected 43.0184)
3.20 ppm -0.4 mDa
50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 m/z
MS 4 [250--C7H9N] +
Expected 143.0604 143.0606
1.40 ppm -107.0725 Da
(Expected 107.0735)
-1.0 mDa
50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 m/z
External Standard Method
The above examples show that the low-mass product ions can
be analyzed precisely and the new compounds can be identi-
n
fied by MS measurement.
Sample provided by: AstraZeneca (UK) Dr. Richard Gallagher
LCMS-IT-TOF
Liquid Chromatograph Mass Spectrometer 7
