Page 5 - Shimadzu LCMS-IT-TOF

CDL DQarray Octopole lens Ion trap Flight tube with temperature control

Atmospheric Ionization Probe Skimmer Lens Detector Dual-Stage Reflectron
In the LCMS-IT-TOF, rather than simply combining the existing tech- speed, ion capture rate and trap saturation associated with the ion
nologies of the QIT (Quadrupole Ion Trap) mass spectrometer and trap, while allowing the advantages of the ion trap and TOF to be
an oaTOF (Orthogonal Acceleration Time of Flight) mass spectrom- fully demonstrated. Abundant qualitative information can be ob-
eter, the QIT and TOF are arranged linearly in a unique construction. tained within a limited HPLC peak elution time.
This construction offsets the disadvantages of slow measurement

High-Efficiency Collision-Induced Dissociation using Argon

Pulsed Ar CID
In the LCMS-IT-TOF, Ar gas is introduced into the trap via a pulse valve to perform cleaning just prior to conducting CID (Collision-Induced
Dissociation). This introduction of Ar has resulted extremely efficient CID.

without Pulsed Argon with Pulsed Argon
60000 60000
m/z 1110 (Precursor ions) m/z 1110 (Precursor ions)
m/z 838 (Product ions) m/z 838 (Product ions)
50000 50000
Signal intensity 40000 Signal intensity 40000
30000
30000
20000 20000
10000 10000
0 0
0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1
CID waveform amplitude (V) CID waveform amplitude (V)
Sample: NaTFA
Without pulsed Ar introduction, product ion intensity noticeably decreases as depending on the m/z value selected; however, with the LCMS-IT-TOF,
the CID energy is increased. On the other hand, with pulsed Ar introduction, equipped with the unique technology of pulsed Ar CID, MS measurement of
n
the product ion intensity remains unchanged even as the CID energy increas- compounds having various m/z’s can be performed under a single set of CID
es. In the case of traditonal ion traps, it is necessary to adjust the CID energy conditions.

Addressing Sharp Chromatographic Peaks…

BIE [Ballistic Ion Extraction]

In the LCMS-IT-TOF, faster spectrum measurement has been achieved by accelerating the
ions from the ion trap to the TOF using a new technology termed Ballistic Ion Extraction
(BIE), which enables high-throughput analysis. BIE is an ion accelerating method to inject
ions into the TOF instantly by applying a high voltage with opposite polarity to the end-caps
and lowering the ring electrode RF voltage to 0V. BIE aids in lowering the spatial distribu-
tion of the ions as they enter the TOF region. +kV 0 V -kV Reflectron

LCMS-IT-TOF
Liquid Chromatograph Mass Spectrometer 5