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Intelligent Automation Improves Work ow Ef ciency






                                                                                                                                                       Automatic optimization of MS conditions

            The combination of the LCMS-8060NX and the Nexera  series UHPLC provides a system with multiple Analytical Intelligence features,          Simply set the sample in place and enter the
                                                     ™
            improving the ef ciency of your entire work ow and maximizing laboratory throughput.                                                       sample information, and MRM and interface
                                                                                                                                                       parameter optimization will be carried out
                                                                                                                                                       automatically. The optimization results are
                                                                                                                                                       shown graphically, reducing the time and
            Intelligent start-up with Smart Flow Control
                                                                                                                                                       effort needed for evaluation.
            HPLC columns can be damaged by sudden pump starts and stops or extreme gradient
            changes. The Nexera automatically uses FlowPilot (Smart Flow Control) to increase the
             ow rate gradually to the set point. There is no need to create startup protocols for
            each analysis.
                                                                                            Column equilibration
                                                                                                                                                                        LC/MS/MS Method Packages and MRM Libraries
                      Pressure without
                      FlowPilot                                                            Auto-purge
                                                                Flow rate                                                                                               Several method packages are available for quick method startup. Analysis can begin
                                     Pressure with FlowPilot    Pressure                                                                                                right away without MRM optimization or tedious method development.
                                                                Oven Temp.                                                                              Optimization
                                                                                                                                                        of analysis
                    1 mL/min                                                                                                                            conditions      ■Method packages                  ■MRM libraries
                                           1 mL/min                                      Startup                                                                                 Target         Cat. No.           Target         Cat. No.
                           0.5 mL/min   ❸                                                                Preparations                                                         Residual Pesticides  C146-E348  Metabolic Enzymes in Yeast  C146-E275
                                                                                                                                                                                                C146-E387
                                                                                                                                                                              Veterinary Drugs
                                                                                                                                                                                                                                  C146-E314
                                                                                                                                                                                                               Phospholipid Pro ling
                              ❷                                                                           for analysis                                                      Water Quality Analysis  C146-E180A
                     ❶                                                                                                                                                     Rapid Toxicology Screening  C146-E406
                                                                                                                                                                                                C146-E401
                                                                                                                                                                            Endogenous Metabolites
                                                   Time                                                                                                                       Lipid Mediators   C146-E381
              Oven    Not Ready          Ready
             status                                                                                                                                                          Cell Culture Pro ling  C146-E408
            Pumping begins                                                                                                           Data               Analysis              D/L Amino Acids   C146-E336
                                                                                                                                                                                Mycotoxins
                                                                                                                                  acquisition           method             Forensic Toxicology Database  C146-E351
                                                                                                                                                                                                C146-E388
                                                                                                                                                        settings
                                                                                                                                                                            Short-chain Fatty Acids  C146-E355
                                                                                                                                                                           Aminoglycoside Antibiotics
                                                                                                               After                                                      Restricted Chemicals in Textiles  C146-E352
                                                                                                                                                                                                C146-E382
            Improves data processing throughput                                                               analysis                                                          Bile Acids      C146-E386
            Great time savings can be achieved in multiple component data analysis, with                                                                                                                  Note: optimization of analysis parameters for the
                                                                                      Data review                                                                                                         LCMS-8060NX is necessary to use some of these products
            functions to check multiple chromatograms at once, display results that exceed
                                                                                      and report                                                     Start analysis
            standard values in a different color, etc. In addition, several report format templates   creation
                                                                                                    Data
            are provided, reducing the time needed for report creation.                                                                                Straightforward pretreatment saves labor
                                                                                                 processing
                                                                                                                                                       The SIL-40 autosampler series has programmable micro-volume liquid handling capabilities. Apply these
                                                                                                                                        Automatic sample
                                                                                                                                        pretreatment   sample pretreatment parameters  from a simple graphic interface, reducing labor and increasing precision in
                                                                                                                                                       co-injection, derivatization, etc.
                                                                                                     Shutdown                                                                       (×10 6 )               (×10 6 )
                                                                                                                                                                                     No co-injection        With co-
                                                                                                                                                                                  5.0                    5.0
                                                                                                                                                                                                            injection
                                                                                                                                                                                  4.0                    4.0
                                                                                                                                                                                  3.0                    3.0
                                                                                                                                                                                  2.0                    2.0
                                                                                                                                                                                  1.0                    1.0
                                                                                                                                                                                  0.0                    0.0
                                                                                                                                                                                        2.0   2.5   min       2.0   2.5    min
                                                                                                                                                                                     Automatic co-injection with water matches mobile phase
                                                                                                                                                                                     conditions, preserving peak shape for early eluters
                                                                                                                                                                                                                       LCMS-8060NX
      8                                                                                                                                                                                                                Liquid Chromatograph Mass Spectrometer  9
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