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Single Nano Particle Size Analyzer Product Information

Evaluation of Raw Materials

Analysis of Plastic Samples by IG-1000 Single Nano Particle Size Analyzer

Biological macromolecules, nanoparticles, and macromolecular nanoparticles made by combining such components are actively being
developed in drug formulation and other fields. For such nano-sized particles, the particle size distribution is one of the most important Plastic Materials Evaluation of
physical properties. The IG-1000 Single Nano Particle Analyzer utilizes the induced grating (IG) technology developed independently by
Shimadzu for measuring the distribution of single-digit nanoparticles dispersed in liquid with high sensitivity and good reproducibility.

Features of the IG-1000 Single Nano Particle Size Analyzer
Measurement Range: 0.5 nm to 200 nm

• Measures the distribution of single-digit size nanoparticles dispersed in liquid with Raw Materials Evaluation of
high sensitivity and reproducibility.
• Accurately measures samples with broad size distributions.
• Free from the tendency to overstate presence of large particles and not be able to
measure small particles.
• Measurement results are unaffected by trace amounts of large particles outside the
measurement range (such as aggregates or contaminants).
• Samples can be measured in normal environments, even without any careful
pretreatment (filtering) processes.
• Allows using raw data (time course variations in intensity of diffracted light) to IG-1000 Single Nano Particle Size Analyzer Product Evaluation
verify the validity of measurement results.

Particle diameters are determined by forming a diffraction a
grating from the particles and then measuring diffusion speed.

The particle diffraction grating is formed using dielectrophoresis.
Samples are placed in a batch cell, then a comb-shaped electrode substrate is inserted Quartz Glass Platinum Comb- Product Information
Shaped Electrodes
into the cell. When an alternating current is applied to the comb-shaped electrodes, Illustration of Electrode Substrates
dielectrophoresis concentrates the particles dispersed throughout the liquid into a Sample Suspension Alternating Voltage
particle diffraction grating pattern. When the alternating current is switched OFF, the Batch Cell
dielectrophoresis stops and the particle diffraction grating pattern begins diffusing.
2a
Diffusion speed is determined from the time course change in
primary diffracted light intensity.
Primary diffracted light is detected by irradiating the particle diffraction grating with
laser light. The primary diffracted light intensity decreases correspondingly as the Diffraction Grating Formed from Particles
(pitch is twice the pitch of the
particle diffraction grating diffuses. In this way, the diffusion speed of the particle comb-shaped electrodes)
diffraction grating is monitored based on the change in primary diffracted light Diffusion of Particle Concentration Diffraction Grating
intensity as a function of time.

In previous systems based on light scattering methods, which use light scattered
from particles as the detected signal, the signal level drops rapidly as the particle size
decreases. That makes it extremely difficult to measure single-digit nanoparticles. In Laser Light
contrast, the IG method uses the primary diffracted light from the macro structure of
a particle diffraction grating as the detection signal. Therefore, the signal level is not
dependent on particle size, making it possible to obtain more than adequate signal Primary Diffracted Light
even from single-digit nanoparticles, which in turn makes it possible to measure Dielectrophoresis Dielectrophoresis
particle size distributions with high sensitivity and reproducibility. (Diffused)
OFF
Particle size is determined from the relationship between particle Intensity of Diffracted Light
size and diffusion speed.
Large particles diffuse slowly and small particles, particularly single-digit nanoparticles,
diffuse quickly. The IG method determines particle size from the relationship between Time
particle size and diffusion speed.

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