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Nexera UC Prep Benchtop system that can be installed anywhere

Semi Preparative Supercritical Fluid Chromatography System Usually a chiller is required to cool the solvent delivery pump when pumping CO2 at high ow rates. However, the Nexera UC Prep
features a compressor-type cooling unit, reducing the size of the system and allowing it to be installed anywhere. Its footprint is
equivalent to an analysis-scale SFC system.
The Nexera UC Prep is a new preparative supercritical uid chromatography system that offers both the high
performance achieved in the analytical Nexera UC model and additional state-of-the-art preparative SFC
technologies. Coolant line Pump
CO2
It resolves a number of issues in preparative tasks, allowing users to overhaul their work ow, reducing CO2 Pump
labor and improving ef ciency. Not only does the Nexera UC Prep achieve superior fractionation recovery Footprint is 84 Cooling
reduced by unit
rates, it provides exible system con gurations in a compact design, requiring low installation space and
allowing you to maximize lab resources. 40% 126

Chiller
Conventional preparative SFC system Nexera UC Prep

Stacked injection function eliminates waiting time

Normal injection wastes time between peak elutions. Using the Nexera UC Prep’s stacked injection function, samples can be
injected continuously without any waiting time, enabling more samples to be processed. Settings for this function can be
speci ed easily in the dedicated software.

Normal injection
Fractionation
Waiting time

3 injections

High recovery rates Injection 10.5 min
3x more injections
In preparative SFC, one factor that results in lower recovery rates is increased dispersion of the eluant when the Stacked injection (9 consecutive injections)
CO2 returns suddenly from a supercritical to a gaseous state. The Nexera UC Prep’s patented gas-liquid separator, Waiting time Fractionation
the LotusStream separator, successfully reduces sample dispersion and carryover, while also achieving high (1) (2) (3) (4) (5) (6) (7) (8) (9)
9 injections
recovery rates. These high recovery rates can be obtained regardless of ow rate or modi er concentration, even
for volatile compounds such as the fragrance linalool.

10.5 min
Comparison for 1% linalool LotusStream separator (1) (2) (3) (4) (5) (6) (7) (8) (9)
Eluent Injection
Equipment Recovery rate (patented technology) Chiral separation of warfarin
Conventional separator 78.0% Decreases ow speeds without
LotusStream separator 96.7% increasing the tubing diameter by Compatible with multiple detectors (max. 4 channels)
splitting ow through multiple ow
channels. The CO2 is discharged CO2 If only the UV signal is used as a trigger in the preparative work ow, components with low UV absorption are dif cult to
externally while the liquid travels separate and there is also a risk of accidentally fractionating unseparated components in the same detection channel. By
along the column and drips directly using the MS signal as the trigger, high-purity fractions can be recovered simply by specifying the m/z value of the target
below without dispersing the eluate. Liquid components.

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