Page 6 - Shimadzu Journal vol.3 Issue3

Insight from Customer

Our LCMS-IT-TOF is particularly useful for high resolution mass
spectrometry. Several years back only a tri-sector mass spectrometer
could achieve such resolution, however we routinely determine the
exact mass of new compounds synthesized here at UWM and our
neighboring institutions and universities. In addition, we are using the
unlimited fragmentation capabilities of this instrument for structural
analysis of unknown metabolites of vitamin D. Our vitamin D
receptor–coregulator inhibitors have anti-tumor activities in respect of
leukemia and ovarian cancer. We are utilizing our LCMS-8040 Triple
Quad instrument with high speed positive/negative ionization
switching for the quantification of drug candidate characteristics such
as microsomal stability, pharmacokinetics, and tissue distribution. In
addition to our specific drug discovery and development programs,
instruments such as the GCMS QP-2010 Ultra with DI probe,
LCMS-2020 single quad, FTIR-IR Tracer NIR/FAR, and a UV-2600
UV-Vis Spectrophotometer support the wide range of basic research
within our Department of Chemistry and Biochemistry. The Shimadzu
Laboratory is meeting its goal to be a unique platform for both
research and chemistry education.
Finally, could you share any requests that you have with
respect to analytical and measuring instrument vendors?
What are Shimadzu’s strengths compared to other
vendors (not limited to the instruments)? We are very happy with our new instrumentation platform, which is
already having tremendous impact on cross-disciplinary research and
We are especially satisfied with the Shimadzu software. It’s very education at UWM. Yet, the analytical facility is relative young and we
intuitive and user friendly and has common operating design across are still exploring expanded areas of research as we look towards new
the various instruments. It has several safety features that prevents collaborations with both academic and industrial partners.
operating errors and encourages preventative maintenance. This is
especially important with a large user group, including a large number
It was significant to know what you think of us and our
of students, and a multidisciplinary institute like the MIDD. More
collaboration. We will strive to meet your request more
importantly, Shimadzu has excellent support with respect to people
than ever. Thank you very much.
and knowledge. I would like to highlight one particular technical
specialist Dr. Nishi Rochelle. As a talented analytical chemist, she has
trained many of your staff and students and helped design and
troubleshoot crucial first experiments that lead to preliminary results
for our NIH and NSF grants and jumpstarted new collaboration and
research. Many other excellent Shimadzu employees have given us
special attention, which differentiates Shimadzu from other
instrument companies and enabled the rapid start-up of a very
sophisticated center.

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