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Insight from a customer
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                            allows hands-on learning using Problem Based Learning techniques that
                                      The oxytocin research and many of the other projects running at MIPS
                              engage students in not only learning about concepts and equations but
                                                            are been used at MIPS and the impact that the Shimadzu laboratory is
                                                        readers about your work.  I hope that we can come back in the future
                                                          and learn some more about the innovative teaching programmes that
                                        now rely on the students having that extra hands-on capability from
                                                      Michelle, thank you for spending some time with me and telling our
                                also in making practical decisions that can be the difference between
                                             programmes are reflected in the fantastic research outcomes right
                                           their undergraduate education.  The importance of our up-skilling
                                                                                       dendrimers increase lymphatic exposure to doxorubicin when
                                                                                                 (5)Wickramaratne Senarath Yapa, S., Li, J., Porter, C.J., Nation,
                                                                                         compared to PEGylated liposomal and solution formulations
                                                                                             issue 1, Elsevier BV, Amsterdam Netherlands, pp. 128-136.
                                                                                           of doxorubicin, Journal of Controlled Release [P], vol 172,
                                                                                   (4)Ryan, G., Kaminskas, L.M., Bulitta, J.B., McIntosh, M.P.,
                                                                                     Owen, D.J., Porter, C.J., 2013, PEGylated polylysine
                                  an analysis that delivers results and one that does not.
                                                                                                   R.L., Patel, K., McIntosh, M.P., 2013, Population  pharmacokinetics of colistin methanesulfonate in rats:  Achieving sustained lung concentrations of colistin for  targeting respiratory infections, Antimicrobial Agents And  Chemotherapy [P], vol 57, issue 10, American Society for  Microbiology, Washington DC USA, pp. 5087-5095. (6)Ryan, G., Kaminskas, L.M., Kelly, B., Owen, D.J., McIntosh,  M.P., Porter, C. J., 2013, Pulmonary administration of  PEGylated polylysine dendrimers: Absorption from the lung  versus retention within the lung is highly size-dependent,  Molecular Pharmaceutics [P], vol 10, issue 8, American  Chemical Society, Washin




                                               across MIPS.  Shimadzu:   having on graduate skills.                                           States, pp. 1-9.




                                fast scanning, fast switching and have sensitivity to generate definitive
                              working is challenging.  To be successful requires the LCMSMS to be
                            Understanding metabolic fate in the concentration range we are











                                      We are making excellent progress. You mentioned the teaching laboratory that Shimadzu supports at  MIPS and it is a project that is very important to us.  In the interests of  space, we might have to come back in a later edition to hear more  about it.  Briefly, what has the project meant for teaching  chromatography in the modern world? You have really hit the nail on the head by talking about the modern  world and the modern student in particular.  Education now is a visual  process more than in previous generations.  The Shimadzu laboratory   Here are her 2013 publications :  Book Chapters (1)Rajewski, R.A., McIntosh, M.P., 2007, Targeting - Theoretical  and Computational Models, in Prodrugs : Chal











                                  data.    Shimadzu:      Dr. McIntosh:














                                                                                   think about it but for poorer nations, the personal and social impact is
                                                              be a project that expresses the wish of all scientists to make a positive
                                                                                     enormous.  Within a single generation, we can change the outcomes
                                                            The oxytocin project is a major part of your work but it also seems to
                                                                           the future of science that there is such engagement in the future of
                                                                               potential to ensure that families grow up with a mother rather than
                                                                         and the awards that have been granted to us.  It does bode well for
                                               disposition.  We were particularly interested in her use of a novel delivery system that is enabling life-changing treatment
                                                                       We are humbled by the recognition that the project has generated
                                                                             preventative medicine.  Quite simply, the oxytocin project has the
                                                                                 that she be lost in child birth.  In the developed world, we do not
                                          Dr. Paul Wynne from Shimadzu Australia had the pleasure of speaking with Dr. Michelle McIntosh, Senior Lecturer at
                                            Monash Institute of Pharmaceutical Science (MIPS) in Melbourne, Australia; about her work in drug metabolism and
                                                                contribution to the world.  How can it move forward?
                                                                                         is a pretty good reason to be working in science. not just for individuals and families but for whole communities.  That  Shimadzu is still a generous supporter and a vital part of the research  and we hope that ultra-sensitive LCMSMS equipment will extend our  ability to study the delivery of the oxytocin during clinical trials.   The LCMS allows you to measure at lower concentrations but aren’t  you also interested in metabolic fate? Both.  We hope that the exquisite sensitivity of the LCMS-8050 will  allow us to measure a variety of biological specimens for oxytocin  without the more extensive sample pre-concentration that is needed  now.  Instrume


                                   Pharmaceutical Science (MIPS), Melbourne, Australia




                                                         Shimadzu:   Dr. McIntosh:                                                          Shimadzu:   Dr. McIntosh:
                               Dr. Michelle McIntosh, Monash Institute of














                                                 for new mothers in third world countries.  Dr. McIntosh, welcome to the Shimadzu Journal. I was hoping that you would be able to tell us a little about your work  at MIPS, your goals for the future and how Shimadzu works as a part   of your laboratory?  Dr. McIntosh:  Our most important project at the moment involves the hormone  Every year, over 100,000 women die of postpartum haemorrhage  (PPH), a condition of excessive blood loss after childbirth. Although  PPH can be effectively prevented or treated with an injection of  oxytocin, access to this drug is limited due to the requirements for  refrigeration, storage and trained medical personnel for  administration. Our team is working on a



                   Insight from a customer








                                                         Shimadzu:
                                                                             oxytocin.




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