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Insight from a customer
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allows hands-on learning using Problem Based Learning techniques that
The oxytocin research and many of the other projects running at MIPS
engage students in not only learning about concepts and equations but
are been used at MIPS and the impact that the Shimadzu laboratory is
readers about your work. I hope that we can come back in the future
and learn some more about the innovative teaching programmes that
now rely on the students having that extra hands-on capability from
Michelle, thank you for spending some time with me and telling our
also in making practical decisions that can be the difference between
programmes are reflected in the fantastic research outcomes right
their undergraduate education. The importance of our up-skilling
dendrimers increase lymphatic exposure to doxorubicin when
(5)Wickramaratne Senarath Yapa, S., Li, J., Porter, C.J., Nation,
compared to PEGylated liposomal and solution formulations
issue 1, Elsevier BV, Amsterdam Netherlands, pp. 128-136.
of doxorubicin, Journal of Controlled Release [P], vol 172,
(4)Ryan, G., Kaminskas, L.M., Bulitta, J.B., McIntosh, M.P.,
Owen, D.J., Porter, C.J., 2013, PEGylated polylysine
an analysis that delivers results and one that does not.
R.L., Patel, K., McIntosh, M.P., 2013, Population pharmacokinetics of colistin methanesulfonate in rats: Achieving sustained lung concentrations of colistin for targeting respiratory infections, Antimicrobial Agents And Chemotherapy [P], vol 57, issue 10, American Society for Microbiology, Washington DC USA, pp. 5087-5095. (6)Ryan, G., Kaminskas, L.M., Kelly, B., Owen, D.J., McIntosh, M.P., Porter, C. J., 2013, Pulmonary administration of PEGylated polylysine dendrimers: Absorption from the lung versus retention within the lung is highly size-dependent, Molecular Pharmaceutics [P], vol 10, issue 8, American Chemical Society, Washin

across MIPS. Shimadzu: having on graduate skills. States, pp. 1-9.

fast scanning, fast switching and have sensitivity to generate definitive
working is challenging. To be successful requires the LCMSMS to be
Understanding metabolic fate in the concentration range we are

We are making excellent progress. You mentioned the teaching laboratory that Shimadzu supports at MIPS and it is a project that is very important to us. In the interests of space, we might have to come back in a later edition to hear more about it. Briefly, what has the project meant for teaching chromatography in the modern world? You have really hit the nail on the head by talking about the modern world and the modern student in particular. Education now is a visual process more than in previous generations. The Shimadzu laboratory Here are her 2013 publications : Book Chapters (1)Rajewski, R.A., McIntosh, M.P., 2007, Targeting - Theoretical and Computational Models, in Prodrugs : Chal

data. Shimadzu: Dr. McIntosh:

think about it but for poorer nations, the personal and social impact is
be a project that expresses the wish of all scientists to make a positive
enormous. Within a single generation, we can change the outcomes
The oxytocin project is a major part of your work but it also seems to
the future of science that there is such engagement in the future of
potential to ensure that families grow up with a mother rather than
and the awards that have been granted to us. It does bode well for
disposition. We were particularly interested in her use of a novel delivery system that is enabling life-changing treatment
We are humbled by the recognition that the project has generated
preventative medicine. Quite simply, the oxytocin project has the
that she be lost in child birth. In the developed world, we do not
Dr. Paul Wynne from Shimadzu Australia had the pleasure of speaking with Dr. Michelle McIntosh, Senior Lecturer at
Monash Institute of Pharmaceutical Science (MIPS) in Melbourne, Australia; about her work in drug metabolism and
contribution to the world. How can it move forward?
is a pretty good reason to be working in science. not just for individuals and families but for whole communities. That Shimadzu is still a generous supporter and a vital part of the research and we hope that ultra-sensitive LCMSMS equipment will extend our ability to study the delivery of the oxytocin during clinical trials. The LCMS allows you to measure at lower concentrations but aren’t you also interested in metabolic fate? Both. We hope that the exquisite sensitivity of the LCMS-8050 will allow us to measure a variety of biological specimens for oxytocin without the more extensive sample pre-concentration that is needed now. Instrume

Pharmaceutical Science (MIPS), Melbourne, Australia

Shimadzu: Dr. McIntosh: Shimadzu: Dr. McIntosh:
Dr. Michelle McIntosh, Monash Institute of

for new mothers in third world countries. Dr. McIntosh, welcome to the Shimadzu Journal. I was hoping that you would be able to tell us a little about your work at MIPS, your goals for the future and how Shimadzu works as a part of your laboratory? Dr. McIntosh: Our most important project at the moment involves the hormone Every year, over 100,000 women die of postpartum haemorrhage (PPH), a condition of excessive blood loss after childbirth. Although PPH can be effectively prevented or treated with an injection of oxytocin, access to this drug is limited due to the requirements for refrigeration, storage and trained medical personnel for administration. Our team is working on a

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Shimadzu:
oxytocin.

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