Page 5 - Shimadzu Tm Analysis System

Reliable Data Integrity Functionality for Satisfying Various Needs

System Configuration 8-Cell Micro Multi-Cell

Tm analysis system consists of the following. This micro multi-cell can be used to measure eight
1 mm Optical Path Length 10 mm Optical Path Length
• UV-Vis Spectrophotometer samples at the same time using the same NEW
Micro Multi-Cell Micro Multi-Cell
• TMSPC-8i 8-cell thermoelectrically temperature controlled cell holder measurement conditions.
• LabSolutions UV-Vis Tm software In addition to previous micro multi-cell models
3.000
with a 10 mm optical path length (with a 100 L 60 µM
minimum sample volume) for satisfying 2.400
high-sensitivity measurement needs, a new model 1.800 40 µM
with a 1 mm optical path length (with a 10 L Absorbance at 260 nm (Abs)
minimum sample volume) for measuring 1.200 20 µM
micro-quantities of expensive samples has been 0.600 12 µM
added to the lineup. Cells with a 1 mm optical path 9 µM
0.000
™
NEW TMSPC -8i UV-Vis NEW LabSolutions UV-Vis Tm length can result in sample evaporation problems, 40.00 50.00 60.00 70.00 80.00 90.00
™
but a new sealing method*, which suppresses the Temperature
evaporation of samples by sealing the top side of Melting Curve of Nucleic Acid (M13 Primer)
(Using Micro Multi-Cell with 1 mm Optical Path Length)
the cell, enables reliable measurement of samples
Data Integrity
with high melting temperatures.
*The sealing method was supported by Professor Junji Kawakami
Tm analysis systems comprise a spectrophotometer, TMSPC-8i 8-cell thermoelectrically temperature-controlled cell (Department of Nanobiochemistry, Faculty of Frontiers of Innovative
Research in Science and Technology (FIRST), Konan University, Japan).
holder, and LabSolutions UV-Vis Tm software. They can automatically determine Tm values based on melting curve
This was supported by AMED under Grant Number JP21ae0121022,
measurements using the average method or derivative method. LabSolutions UV-Vis Tm can provide the industry’ s JP21ae0121023, JP21ae0121024 (Project leader: Satoshi Obika).
highest data integrity levels when linked to a LabSolutions DB/CS system, which has an extensive track record from use
with LC, GC, and many other analytical instruments.
Real-Time Transfer Function and Thermodynamic Parameter Analysis

Client PC Laboratory or office LabSolutions server
LabSolutions UV-Vis Tm can transfer temperature,
Temperature
absorbance, and time values to an Excel file in real Real-time data
®
transfer
time during measurements.
Absorbance
Acquisition controller PC By transferring Tm values obtained from samples X
with different concentration levels to commercial Time
spreadsheet software, changes in Gibbs free energy
values used as an index for drug activity levels or
thermodynamic properties, such as entropy or
enthalpy, can be analyzed easily.

Note: LabSolutions DB UV-Vis: This is a stand-alone database management system which analysis software on a single PC.
LabSolutions CS system: A server, client, and acquisition controller are connected on the network. The data of all devices are centrally managed by the
database built on the server. User and permission management is centrally managed with this system.

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