Page 3 - Shimadzu Tm Analysis System
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Tm Analysis System









 Tm analysis systems can accelerate the development process and improve the

 quality of oligonucleotide therapeutics. Control by LabSolutions  software enables
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 compliance with ER/ES-related regulatory requirements and improves the
 efficiency of analyzing the thermal stability (Tm analysis) of nucleic acids.













 Reliable Data Integrity

 The Tm analysis system in conjunction with LabSolutions DB/CS can achieve the highest data integrity
 levels in the industry. Measurement parameters, audit trails, and results of data acquisition and analysis
 are managed in a database protected with user privilege settings and security policies to prevent
 unintended operations or data tampering by operators.








 Functionality for Satisfying Various Needs
               Tm Analysis
 In addition to trace measurement and high-sensitivity measurement capabilities required for Tm analysis,
 the system also satisfies a variety of other needs, including thermodynamic parameter analysis using   Melting Curve
               Tm analysis serves an important role in checking the
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 functionality for automatically transferring data to an Excel  file.
               thermal stability and sequence of nucleic acids. In Tm                        Single-Strand
               analysis, heat is applied to the nucleic acids in
               double-strands. Then, the change in absorbance     Double-Strand
               (melting curve) that occurs as the temperature increases   Absorbance at 260 nm (Abs)  Tm Value
               and the strands dissociate into single strands is
 Efficient Automated Workflow  measured. The melting temperature (Tm value) is

 Tm analysis system dramatically decreases the time and trouble required for Tm analysis by automating all   determined as the temperature where the mole
 steps (particularly the time-consuming annealing and analysis steps).  fractions of single and double strands are equal.  Temperature



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 Note: The photo on the right shows the UV-2600i ultraviolet-visible spectrophotometer with a TMSPC -8i 8-cell thermoelectrically temperature-controlled cell
 holder connected. However, the TMSPC-8i can be also connected to either UV-1900i or UV-2700i models.
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