Page 3 - Shimadzu SALD-7500nano

High-sensitivity Measurement of Wide Measurement Range: 7 nm to 800 µm
From primary particles to sub-visible particles and contaminants
Nano Particle Size Distribution

Changes in particle size across the 7 nm to 800 µm measurement range can be continuously measured using a
A powerful new tool for research and development in nanotechnology single light source, single optical system and single measurement principle.
and life sciences, and for measuring fine bubbles. Since a primary particle and an aggregate and contaminant can be measured with one system,
the aggregation properties by a dispersion condition can be checked.
Primary particle size
Evaluation of the dispersion and aggregation characteristics of particles is realized with a wide Primary particle size Primary particle size
measurement range and in real time. The evaluation of the dispersion and aggregation
characteristics of the particles is realized with a
The SALD-7500nano was developed to provide accurate and high-sensitivity wide measurement range and in real time.
measurement of low concentration or high-light absorption nano particles. It achieves sensitivity in the nano
area about ten times higher as compared to conventional instruments. In addition, low concentration samples Particle size
of less than 1 ppm can be measured. Particle size Particle size

Enables measurement of fine bubbles (micro bubbles from 100 nm to 60 µm), and allows real-time tracing of
the changes in the bubble diameter. 1-Second Minimum Serial Measurement Time. Real time monitoring

This system enables the evaluation of sub-visible particles included in biopharmaceuticals. By incorporating a single light source, which does not require switching, and the wide-angle detection method,
Special options can be added to create an aggregation analysis for biopharmaceuticals. the measurement time can be reduced to a minimum of 1 second. In addition, the particle size distribution can be
displayed in real time at 1-second intervals.
Serial observations of the dispersion, cohesion or dissolution reaction processes are possible at 1-second intervals, and these
results can be saved. Functions for statistical processing and 3D display of the particle reaction processes offer multifaceted
analyses and evaluations.
Connecting the flow cell directly to the fine bubble generator enables in-line real-time monitoring of the changes in
fine bubbles.
Measurement unit Wing sensor II
Drain Pump Flow cell
Side scattered
light sensor
Nomalized Particle Amount
Laser light source
Backward scattered Condensing lens
light sensor
Fine bubble generator
Particle Diameter
In-line real time monitoring of
Water supply
the change in a fine bubble

Measure Concentrations from 0.1 ppm to 20 %

Compared to other instruments, the SALD-7500nano permits measurements across an extremely broad
concentration range of 0.1 ppm to 20 %.
The particle size of fine particles, particularly nano particles, varies with the concentration.
The dispersion and coagulation of nano particles can be observed while altering the concentration.
Accurate analysis of samples in which the particle size distribution changes with dilution is possible, as
measurements can be conducted on the undiluted solution or after minimal dilution. For example, commercial
hand creams, face creams, and rinses can be measured with hardly any pretreatment.

Measurement of Small Sample Amounts

Nano Particle Size Analyzer Drainage of a small quantity of a suspension liquid is adequate since the SALD-BC75 batch cell permits analysis of a
SALD-7500nano volume of just 5 cm . Most organic solvents can be used.
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A combination of the SALD-HC75 high-concentration measurement unit with special glass slides featuring
a shallow indentation permits measurement on just 15 micro liters.