Page 11 - Shimadzu Nexera UC

Easy and efficient method scouting for separating chiral compounds Innovative technologies packaged into robust modules

Automatically performs a variety of method scouting processes Customized modules for Nexera UC based on Nexera technology

The high-speed performance of SFC can shorten the time required for method scouting. Supercritical Fluid Extraction Unit SFE-30A
It automatically generates a large number of methods by utilizing combinations of up to 12 columns, four modifiers, and
This unit operates at a maximum temperature of 80°C to allow faster and more complete extractions.
different ratios of modifiers to mobile phase.
Two sizes of extraction vessels (5 mL and 0.2 mL) can be chosen based on the sample amount.
This unit has the internal capacity to run up to four samples automatically; with the addition of an optional rack changer, it
can accommodate unattended operation for up to 48 samples.

Rack changer: max. 48 samples Two sizes of extraction vessels

CO2 Solvent Delivery Unit LC-30ADSF / Back Pressure Regulator Unit SFC-30A
Stable baseline with low pulsation is realized by LC-30ADSF with a built-in cooler for pump heads, which delivers mobile phases up to
5 mL/min at pressures up to 66 MPa. The low dead volume of SFC-30A (0.7 µL) allows a mass spectrometer to be directly connected
to the SFC system without splitting so that higher sensitivity can be achieved.

A screen shot of Method Scouting Solution for Nexera UC user interface.

Chiral analysis with “Nexera UC Chiral Screening System”

SFC-30A
®
CHIRALPAK Series and CHIRALCEL Series columns (Daicel Corporation) for chiral analysis are capable of resolving a wide
®
variety of compounds by showing complementary separation targets. LC-30ADSF
The combination of the Nexera UC Chiral Screening System and these columns simplifies method scouting for chiral analysis.
Nexera UC reduces environmental impact

mAU
300 Indapamide Comparison of costs and consumption of organic solvent for a single analysis by conventional normal-phase LC vs. SFC is shown below.
RT = 2.644
Rs = 2.66 By using SFC, the total cost of analysis is reduced by 87.6% and the consumption of organic solvent is reduced by 94.2%.
200

100
Hexane/
Normal phase LC 30,126 JPY Isopropanol
0
= 99:1
(Normal phase LC)
0.0 1.0 2.0 3.0 4.0 5.0 min 12.00 mL
Columns: CHIRALPAK AD-3
Modifier: Acetonitrile/Ethanol=7/3 Nexera UC 3,745 JPY 87.6% reduced Methanol 0.70 mL 94.2% reduced
(Nexera UC)

CHIRALPAK ® and CHIRALCEL ® are registered trademarks of Daicel Corporation. Comparison of costs Comparison of organic solvent consumption

Nexera UC
10 Supercritical Fluid Extraction/Chromatograph System 11