Page 6 - Shimadzu LCMS-9050
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Ultra-stable polarity switching





                     Shimadzu's breakthrough innovation challenges the common belief that TOF instruments cannot undergo
                     efficient polarity switching. With the capability to achieve low-ppm mass measurement accuracies in short
                     switching intervals, possibilities are now open to enhance the workflow with greater confidence and ease.



                     Achieving Both Polarity Switching and
                     Mass Accuracy


                       Measure   Measure  Measure   Measure   Measure   The LCMS-9050 features a proprietary
                       Positive  Negative  Positive  Negative  Positive
                       ions      ions     ions      ions      ions      high-precision electrical circuit and the
                                                                                    ™
                               Switch   Switch   Switch    Switch       UFstabilization  algorithm (patent pending)
                               polarity  polarity  polarity  polarity   that make polarity switching both fast and
                     Illustration of Switching between Positive and Negative Ion Modes  stable.






                     Positive Ion Mode             Temp.             Negative Ion Mode
                                                        30                                                30
                        8                                               8
                                                        26              4                                 26
                      Mass Error [ppm]  0               22  Temp. [°C]  Mass Error [ppm]  0               22 18  Temp. [°C]
                        4
                                                        18
                        4
                                                        14              4                                 14
                        8                                               8
                                                        10                                                10
                         0    12   24   36   48   60   72               0     12   24    36   48   60   72
                                      time [h]                                         time [h]



                     Positive-Negative Switching Mode


                                                                    Positive ion Mode, Negative ion Mode: No calibration
                       10                                   30
                        8
                                                                    Mass error was within ±2 ppm even throughout 3 days of
                        6 4                                 26      continuous analysis.
                      Mass Error [ppm]  2 0 2               22 18  Temp. [°C]  Positive-Negative Switching Mode: External calibration
                                                                    Calibrants were transiently introduced via a sub-interface in
                        6 4                                 14      between sample analysis for mass correction. The mass accuracy
                        8                                           was within ±3 ppm throughout 40 hours of continuous analysis.
                       10                                   10      Both were analyzed under normal laboratory conditions.
                         0       10      20       30       40

                                        time [h]
                      Anisomycin(+)  Griseofulvin(+)  Valinomycin(+)  Doxorubicin(-)  Salinomycin(-)  Cyclosporine(-)



                                     Results of analyzed 6 antibioticcomponents continuously



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