Page 6 - Shimadzu LCMS-9050

Ultra-stable polarity switching

Shimadzu's breakthrough innovation challenges the common belief that TOF instruments cannot undergo
efficient polarity switching. With the capability to achieve low-ppm mass measurement accuracies in short
switching intervals, possibilities are now open to enhance the workflow with greater confidence and ease.

Achieving Both Polarity Switching and
Mass Accuracy

Measure Measure Measure Measure Measure The LCMS-9050 features a proprietary
Positive Negative Positive Negative Positive
ions ions ions ions ions high-precision electrical circuit and the
™
Switch Switch Switch Switch UFstabilization algorithm (patent pending)
polarity polarity polarity polarity that make polarity switching both fast and
Illustration of Switching between Positive and Negative Ion Modes stable.

Positive Ion Mode Temp. Negative Ion Mode
30 30
8 8
26 4 26
Mass Error [ppm] 0 22 Temp. [°C] Mass Error [ppm] 0 22 18 Temp. [°C]
4
18
4
14 4 14
8 8
10 10
0 12 24 36 48 60 72 0 12 24 36 48 60 72
time [h] time [h]

Positive-Negative Switching Mode

Positive ion Mode, Negative ion Mode: No calibration
10 30
8
Mass error was within ±2 ppm even throughout 3 days of
6 4 26 continuous analysis.
Mass Error [ppm] 2 0 2 22 18 Temp. [°C] Positive-Negative Switching Mode: External calibration
Calibrants were transiently introduced via a sub-interface in
6 4 14 between sample analysis for mass correction. The mass accuracy
8 was within ±3 ppm throughout 40 hours of continuous analysis.
10 10 Both were analyzed under normal laboratory conditions.
0 10 20 30 40

time [h]
Anisomycin(+) Griseofulvin(+) Valinomycin(+) Doxorubicin(-) Salinomycin(-) Cyclosporine(-)

Results of analyzed 6 antibioticcomponents continuously

6