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Solutions for
                  Clinical Research                                                                    Index



            Application Notebook



            Therapeutic Drug Monitoring
              High-Throughput Optimization of Therapeutic Drug Monitoring Using Fully Automated Sample Preparation
              LC-MS/MS System (CLAM-2000 + LCMS-8040)
              This article introduces the results of TDM using a fully automated sample preparation LC-MS/MS system comprised of the CLAM-2000 fully automated
              LCMS sample preparation unit and the LCMS-8040 high performance liquid chromatograph-mass spectrometer. This system resolves the problems
              associated with TDM, and achieves TDM research results on a fast and high-precision analytical work ow.
              Simultaneous Analysis of Antiarrhythmic Drugs in Human Blood Plasma Using the Fully Automated Sample
              Preparation LC-MS/MS System
              This article introduces a study which achieves a fast and simultaneous analysis work ow of six antiarrhythmic drugs with the fully automated sample
              preparation LC-MS/MS system. The analysis method used by this system is a fast and low-burden analysis technique that achieves quantitative results
              equivalent to conventional manual pretreatment methods and we anticipate its utilization into the future.
              Evaluation of Blood Lysis Procedures prior to Automated Sample Preparation for Immunosuppressant Assay by
              LC-MS/MS
              Absorption value was measured by UV-Visible spectrophotometer to evaluate Lysis ef ciency for automated sample treatment LC-MS/MS analysis.
              High-sensitivity and Simultaneous Analysis of Psychoactive Drugs Using LC-MS/MS with Full-Automated
              Pretreatment System
              In this study, we investigated the processing capability to analyze serum, whole blood and urine spiked sixty psychotropic drugs by LC-MS/MS with
              automated sample preparation unit. The results show the capability of the system for large sample set analyses with improved accuracy and precision by
              eliminating human error associated with manual sample handling.
              A Fast LC-MS/MS Method for Quantitative Analysis of Five β-LactamAntibiotics in Human Plasma
              A fast MRM-based method for quantitation of  ve β-lactam antibiotics tazobactam, cefepime, meropenem, ceftazidime and piperacillin in human
              plasma was developed. A simple sample pretreatment with protein crash by organic solvent was applied and a small injection volume of 2 µL was
              required due to the high sensitivity of the LCMS-8060 employed.

            Endocrinology
              Evaluation of an Automated LC-MS/MS System for Analyzing Hydrophilic Blood Metabolites
              In this study, we assessed whether the plasma levels of metabolites could be quantitatively measured using a fully automatic pretreatment system for
              LC/MS that can be connected online to an LC/MS device.
              Determination of Unbound Urinary Amino Acids Incorporated with Creatinine Normalization by LC-MS/MS Method
              with CLAM-2000 Online Sample Pretreatment
              The aim of this study is to develop a reliable LC-MS/MS method for quantitation of 22 free amino acids and creatinine in urine samples.
              A derivatization-free LC-MS/MS amino acid method with stable isotope labelled IS was employed.
              Measurement of Enzymatic Activities in Dried Blood Spots with On-line Solid Phase Extraction-LC-MS/MS System
              In this application, a protocol developed at the Meyer Children's Hospital, Mass Spectrometry, Clinical Chemistry and Pharmacology Laboratory
              (Florence, Italy) was used to measure the enzymatic activity in dried blood spots (DBS) using an online solid phase extraction (SPE) – LC-MS/MS system.
              Integration of Amino Acid, Acylcarnitine and Steroids Analysis in Single FIA/LC-MS/MS Platform
              In this study, we present a strategy for performing both amino acids (AA)/ acylcarnitines (AC) and steroids analysis within a single LC-MS/MS platform.
              All compounds were extracted from only one dried blood spot. This system enables to automatically analyze 7 min in all target analytes in 2 injections.

            Clinical Toxicology
              A Novel Platform of On-line Sample Pretreatment and LC-MS/MS Analysis for Screening and Quantitation of Illicit
              Drugs in Urine
              This platform, CLAM-2000 module coupled with Shimadzu LCMS-8040 was applied and evaluated for quantitation of 18 illicit drugs with 14
              isotope-labelled internal standards. The method performance was evaluated on the linearity, accuracy, speci city and process ef ciency.
              Screening Analysis of Highly Polar Doping Agents in Urine Using 2D LC-MS/MS
              In this application news, we report the simultaneous analysis of highly polar doping agents including meldonium and adrenergic agents such as
              synephrine, norfenefrine, etilefrine, oxilofrine and octopamine using 2D LC-MS/MS.
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