Page 15 - Clinical-Medical Physical Properties of Biomaterial

Evaluation of Pharmaceuticals and Packaging Most tablets and capsules are packaged with a combination of aluminum or other thin metals and
PTP Packaging Evaluations
Evaluation of Biological Samples Medicinal agents are administered in a variety of forms including tablets, and visibility. functions to protect tablets and capsules. Accordingly, quality control is necessary to ensure that the Evaluation of Biological Samples
plastic. This sort of packaging is referred to as PTP (press through package) or a PTP sheet. It

packaging does not come unstuck indiscriminately, and that the medicine is not hard to extrude.
Pharmaceuticals, packaging, and materials manufacturers use testing equipment
capsules, granules, and liquids. Storage containers also vary from glass to plastic,
for quality control and new product development. The applications include the
and are used in response to respective applications. Pharmaceuticals and
development of materials, evaluation of the result of sterilization, and evaluation
packaging are manufactured with attention to even the smallest aspects,
of physical properties such as the force required to open the packaging.
including functionality, ease of conveyance and removal, ease of administration,
Extrusion Testing of PTP Packaged Tablets
Evaluating the Strength of Tablets
Tablet extrusion force 24.3 N
24 30 28 26 Tablet extrusion force 24.3 N
PTP packaging extrusion tests involve evaluating the ease of use when a 22
Tablets are solid pharmaceutical products, formed into a set shape by methods such as compression molding of active 20
person removes the tablets. The PTP packaged tablet is pressed between top 18
ingredients, or a combination of active ingredients and diluents. Tablets are portable, making it easy to administer a set dose, Test force (N) 16 14
and bottom plates with holes in them. The tablet is extruded from the top by 12
and represent the most familiar method of administering medicine in our daily lives. an extrusion jig, at which point the amount of jig movement and the test 10 8 6 4 2 0
Evaluation of Biomaterials Equipped with a wealth of testing functions, EZTest is a compact table-top universal tester that can be used for a variety of Compact Table-Top Universal Testers PTP packaged tablet's extrusion strength. The strength must be such that the Test force (N) 2.8 4 0 End test force 0.3 N 2 2.4 End peeling force 3.0 N Evaluation of Biomaterials
With consideration to ease of handling and swallowing, most tablets weigh between 200 mg and 500 mg, and have a diameter
force are measured. The maximum test force at this point is equivalent to the
of about 8 mm to 15 mm. They come in a variety of shapes including disc-shaped, lens-shaped, and rod-shaped tablets.
1.2
3.6
2.8
1.6
4
0.4
0.8
3.2
Displacement (mm)
tablet is easy to remove but is not extruded arbitrarily.
testing applications, including evaluations of tablets, solder peeling strength measurements for electronic parts in medical
End peeling force 3.0 N
3.6
devices, and strength tests and peeling tests for packaging. Naturally, EZTest is compatible with various grips and extensometers,
3.2
EZTest Series
as well as testing in thermo-constant environments.
Peeling Testing of PTP Packaging
2.4
2.2
End test force 0.3 N
When medicines are transported, friction may lead the packaging to come
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Compression Testing and Score Line Strength Evaluation of Tablets
unstuck. PTP packaging peeling tests simulate such circumstances. The PTP
0.8
0.4
packaging peeling test is performed by unsticking a part of the PTP 1..6
Many tablets are formed with a midline splitting groove to make them easier to swallow and for use with children. The depth of the depression is investigated to ensure that the 0 0 1 2 3 4 5 6 7 8 9 10
packaging, and then gripping the peeling part and applying tension. Displacement (mm)
tablet can be split in half easily. Here, a three-point bending test jig is used to perform a three-point bending test on a tablet in order to measure the midline splitting strength.
30 Tablet splitting test force 24.2 N Adhesive bandages, a type of hygienic material used to prevent infections
Tablet splitting test force 24.2 N
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Evaluation of Medical Equipment Test force (N) 18 8 6 4 2 0 0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16 0.18 0.2 and the penetration of bacteria by adhering to an affected body part, are Evaluation of Medical Equipment
Tear Off and Tensile Testing of Adhesive Bandages
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24
22
20
16
14
classified as general medical equipment. A variety of evaluations is
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10
performed on bandages, which are an everyday part of our lives. These
include adhesion to skin, ease of peeling, tensile strength, and the force
required to open the packaging. In peeling tests, a bandage affixed to a
stainless steel flat plate is peeled off at a 180° angle. Sometimes, peeling
Displacement (mm)
Tablet Compression Test
same tests are also performed on compresses and other medical goods
besides bandages that are affixed directly to the skin.
Molding Test of Tablet Powder Tablet Score Line Strength Test tests are performed on bandages actually stuck to a person's skin. The
Evaluation of Pharmaceuticals and Packaging compressing the powder, the loading and compression speed must be controlled very accurately. Evaluation of Pharmaceuticals and Packaging
Tablets are produced through compression molding of pharmaceutical powders. When a tablet is molded, a set
Strength Test of Packaging
quantity of powder must be formed into a single tablet. It is also important that the tablet satisfies a number of
functional conditions. For example, it must not break if dropped and must dissolve easily. Accordingly, when
This test device is suitable for experimental determination of the affinity of particles, work load required for
molding, and the influence of additives when molding powders, at different molding speeds and load levels.
The test forces of the upper and lower mallets are individually
detected by load cells, and the displacement between the
upper and lower mallets is detected by the differential
transformer detector. These enable effective data measure-
ments with respect to molding powders, including wall
friction and compression volume.
Molding Property Test Device for Powder Samples Piercing Test of Film Compression Test of Containers 180° Peeling Test on Package Crimping Press-Dispense Test of Tablets
Physical Property Testing Equipment
for Biomaterials and Medical Applications
14 Solutions for Biomedical Testing 15