Page 3 - Shimadzu Journal vol.5 Issue1

CONTENTS

Featuring Clinical Research

Insight from Customer
Professor Daniel W. Chan from the Johns Hopkins University School of Medicine 04
We interviewed Professor Daniel W. Chan from the Johns Hopkins University School of Medicine. His research is focused on the
development and application of proteomic and immunologic techniques in the diagnosis, management, and understanding of cancer.
The relationship with Shimadzu started in 2009 when the Johns Hopkins Center for Biomarker Discovery and Translation began utilizing
Shimadzu's mass spectrometers (AXIMA QIT and Resonance), primarily for discovery and analysis of cancer-related glycoforms.

Glycan Analysis
n
Analysis of Glycan Structures Using Chemical Labeling and MALDI MS Mass Spectrometry 06
Glycans play important roles in the function of glycoproteins in the human body. In this study, an AXIMA ResonanceTM was used to generate
MALDI-IT-TOF MSn spectra for the analysis of glycan sequences without multistep separation or enzymatic treatment. Combining the
carbohydrate oxidation reaction and MSn analysis allowed monitoring the oxidization reaction for sialylation and linkages of oligosaccharides.

Neuroscience
The Grand Challenge to Understand the Brain: Neuroimaging by Near-infrared Spectroscopy 09
After describing the overview of the recent study of the brain and neurosciences, the development of brain imaging technologies has
been mentioned to have contributed extensively to a major branch of neuroscience focused on the correlation of functional brain activity
with cognition and behavior. Because the interactive social behavior involving dynamic communications between two individuals is a
fundamental aspect of human socialization, the acquisition of real-time NIRS signals of two individuals is a solution for this purpose.

Posters from ASMS 2017 15
These articles were selected by Shimadzu. Relating to clinical research, they derive from posters presented at ASMS 2017, held June
4-8 in Indianapolis, IN. They feature Shimadzu's state-of-the-art mass spectrometry lineup and include cutting-edge technologies.

Bioanalysis
Application of LC-MS/MS Analysis for Time-lapse Metabolomics in CHO Cell Culture 18
Metabolic analysis of Chinese hamster ovary (CHO) cell culture plays an important role for efficient production in the biopharmaceutical
industry. In this study, amino acids concerned with these pathways were analyzed by LC-MS/MS (LCMS-8050, SHIMADZU) for time-lapse
metabolic analysis of CHO-K1 cell batch culture. Results showed real-time changes of various metabolites during CHO culture, which may
provide extensive and speedy investigational analysis for genomic and metabolic modifications in biopharmaceutical or medical progresses.

Topics
Shimadzu Global Innovation Summit 2017 - IMAGINE, INNOVATE & INSPIRE - 23
Shimadzu Corporation held its first Global Innovation Summit in Kyoto, Japan, July 4th & 5th, 2017. The event brought together over 100
scientists from 16 countries in the fields of analytical chemistry and medical diagnostics including 11 Key Opinion Leaders (KOL) who spoke about
their application of Shimadzu products to research pressing issues in the areas of human health, food safety and environmental conservation.
Topics
Collaboration Between Shimadzu, The Systems Biology Institute, and Osaka University Starting 25
the Provision of an Open Platform Multi-omics Data Analysis Pack
On June 6, Shimadzu Corporation starts to provide, at no cost, the Shimadzu Multi-omics Data Analysis Pack. Intended for metabolic engineering, this gadget pack
automatically visualizes large-volume of data sets from proteomics*1, metabolomics*2, and flux analysis*3, obtained using Shimadzu gas chromatograph mass
spectrometers and liquid chromatograph mass spectrometers, on metabolic maps and perform a variety of data analyses. Multi-omics is a cutting-edge research area
in the field of life sciences. It involves the integrated analysis of changes in genes, proteins, metabolites and other substances, towards a holistic elucidation of
biological activities at cellular level. Multi-omics is expected to be useful in a variety of fields such as drug discovery, diagnostics, and biofuel research.

Topics
Shimadzu Corporation and Phytronix Technologies sign an agreement to offer the first Triple 26
Ion Source (LDTD-MS/MS, ESI-MS/MS and APCI-MS/MS).
Kyoto, Japan and Québec, Canada – June 5, 2017. Shimadzu, one of the world's fastest growing mass spectrometry companies, and Phytronix,
world leader in high throughput analysis in mass spectrometry, announced that they had signed an agreement to offer the industry’s first Triple Ion
Source. Ideal for both screening and confirmation work, this new high-speed platform will significantly improve productivity in high-throughput
laboratories performing toxicology, drug discovery and food safety applications. This Triple Ion Source incorporates the Phytronix LDTD (Laser Diode
Thermal Desorption Ion Source), and is designed in perfect synchronization with the speed of the Shimadzu LCMS-8060 triple quadrupole mass
spectrometer. Together, the companies presented information about this new design at ASMS in Indianapolis.
New Products
Nexis GC-2030 (High-End Gas Chromatograph), SPM-8100FM (High Resolution Scanning Probe Microscope), LC/MS/MS Method
Package for D/L Amino Acids, Semi-Micro Analytical Balances AP-W Series (Advanced Performance UniBloc Balances) 27