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Dear Reader, CONTENT
Director’s note Welcome to the second issue of Shimadzu Journal, in which we introduce Focused on Pharmaceuticals and Human Science
collaborative research projects as well as industry-specific technical reports and
applications. As reflected in our brand statement, "Excellence in Science," this
journal exemplifies our desire to work with leading researchers around the globe Insight from a customer
and address customers’ requirements by offering superior, world-class Professor Richard B. van Breemen, University of Illinois, Chicago, USA 30
technologies. We interviewed Professor Richard B. van Breemen who is studying medicinal properties of natural products at the
University of Illinois, College of Pharmacy, in Chicago, using advanced mass spectrometry.
The Analytical and Measuring Instruments Division continues to develop and Human Health
manufacture analytical instruments that deliver results faster and more efficiently Quantitative Analysis of Bisphenol A in Water and Serum Using UHPLC-MS-MS 32
than ever before to meet the needs of researchers, scientists, and manufacturers Endocrine disruptors represent a major toxicological and public health issue, and the xenoestrogen bisphenol A (BPA) has
around the globe. These state-of-the-art solutions are used in a wide variety of received much attention due to its high volume of production for plastics and widespread human exposure. The measurement
fields that impact the health and lives of people. of BPA in biological and environmental samples is essential for risk assessment. However, such analyses are challenging due to
the trace levels of BPA in these samples and the possibility of false positive determinations due to background contamination.
Currently, pharmaceuticals, life science, and food safety are the main fields of our Customer interviews
concern. Collaborating with researchers is vital to us as a manufacturer in order to Unique & Innovative Functions for Next Generation Separation Technologies 35
develop new solutions that contribute to society. For that reason, the Shimadzu We interviewed customers about Shimadzu's new innovative technologies: iPDeA (Intelligent Peak Deconvolution Analysis)
Journal introduces various collaborative research projects and the potential impact and iDReC (Intelligent Dynamic Range Extension Calculator)
they may have on society.
Technical Report
For this issue, we have focused on pharmaceutical analysis. It contains Fractional Determination of Co-eluted Compounds Using a New Data Processing Method for Photodiode Array Detector: 39
information on three collaborations. One is with Professor van Breemen of Principle and Summary of i-PDeA (Intelligent Peak Deconvolution Analysis)
University of Illinois, Chicago, USA, who is studying medicinal properties of The i-PDeA derivative spectrum chromatogram method was developed as a new data processing technique for
natural resources, such as lycopene in tomatoes, with advanced mass photodiode array detectors for HPLC. A derivative spectrum is created by performing differential processing on the
spectrometry. An interview with Professor van Breemen provides details on his UV-Vis absorption spectrum at each measurement time. Plotting the derivative spectrum values at the specified
wavelength against retention time creates a derivative spectrum chromatogram that is able to separate co-eluted peaks.
current studies. The second and third collaborations are with Japanese
pharmaceutical companies developing new technologies for the Nexera X2 series, Technical Report
Shimadzu’s flagship liquid chromatograph. In addition, information on other New Data Processing Method for Photodiode Array Detector : 43
applicable topics, as well as the latest news and applications are included. Principle and Summary of i-DReC (Intelligent Dynamic Range Extension Calculator)
A new data processing method for a photodiode array (PDA) detector, Intelligent Dynamic Range Extension Calculator
We will always strive to develop the highest technology and seek valuable (i-DReC) enables the automatic calculation of peak area and height, utilizing spectrum similarity in the high concentration
solutions that meet the needs of customers throughout the world. We wish to be range where UV signal is saturated. When the integrated chromatographic peak area exceeds a user-defined threshold value,
i-DReC automatically shifts the chromatographic profile to a wavelength with less UV absorption to prevent signal saturation.
a good partner for you, and hope this Journal provides valuable insight and
information that benefits you and your colleagues.
Posters from Recent Conferences 47
These posters were presented at ASMS 2013 (June 9-13, 2013, Minneapolis) and HPLC 2013 (June 16-20, Amsterdam).
Click the title URLs to download the posters of interest.
Topics
High-Throughput Bioanalysis with On-Line Sample Pretreatment 50
Using Restricted Access Media The Shimadzu Co-Sense for BA System Solution
Yours Sincerely, In conjunction with Eisai Co., Ltd., Shimadzu has developed and commercialized unique restricted access type trap columns
(Shim-pack MAYI series) and an LC system with on-line pretreatment functionality via valve switching (Co-Sense for BA). The
Co-Sense for BA allows large volumes of plasma, serum and other biological samples to be injected and analyzed.
Latest News
Teruhisa UEDA, PhD. Shimadzu’s Diffraction Grating Goes into Space 55
Shimadzu's diffraction grating was launched with the Spectroscopic Planet Observatory for Recognition of Interaction
of Atmosphere (SPRINT-A) by the first Epsilon Launch Vehicle (Epsilon-1) on September 14.
Latest News
General Manager, Analytical & Measurement Instruments Division
Shimadzu’s HMV-G Series Micro Vickers Hardness Testers Receive the 2013 56
Silver Award for Industrial Design
Shimadzu’s HMV-G Series Micro Vickers Hardness Testers were recognized by Instrument Business Outlook (IBO) as its 2013 Silver
Award for Industrial Design for Analytical Instruments for their outstanding modern and bold design. With a curved frame softened
by a bright color scheme, the HMV-G Series’ appearance tells both technical sophistication and robustness and accessibility.
Latest News
Collaboration with Analysis Center of Tsinghua University in China 56
Shimadzu has been collaborating with Analysis Center of Tsinghua University since 2004 in cultivating young talent via an
internship program, providing analytical instruments, and giving technical advice and maintenance support.
New Products
LCMS-8050, IRTracer-100, Aggregates Sizer, EDX-7000/8000 57
