Page 67 - Application Notebook - PFAS Analysis

No. SSI-LCMS-120

Table 4: Summary P&A with QQQ LCMS-8045.

QQQ 25 ppt P&A True Value Avg Avg.%REC %RSD Std Dev
PFBS 22.2 25.6 115 2.5 0.629
PFHxA 25 25.6 103 3.9 1.01
HFPO-DA 62.5 67.2 108 3.7 2.46
PFHpA 25 26.4 106 3.6 0.954
PFHxS 32.8 26.4 80 4.1 1.09
ADONA 25 39.7 159 3.2 1.29
PFOA 25 25.1 100 2.5 0.619
PFNA 23.1 25.8 112 3.1 0.797
PFOS 25 25.7 103 3.6 0.936
9Cl-PF3ONS 23.2 27.7 119 2.9 0.809
PFDA 25 23.4 94 2.9 0.686
N-MeFOSAA 25 31.4 126 5.6 1.75
N-EtFOSAA 25 34.8 139 5.5 1.90
PFUnA 25 24.1 96 3.6 0.875
11Cl-PF3OUdS 23.5 46 196 4 1.85
PFDoA 25 23.5 94 2.8 0.665
PFTriA 25 24.4 98 3.8 0.916
PFTreA 25 25.2 101 2.9 0.726

Figure 3: Comparison LOQ from QTOF LCMS-9030 and QQQ LCMS-8045.

■ Conclusions
Comparable quantitative results can be obtained by EPA Method 537.1 allows for additional compounds
using either a LCMS QQQ or a LCMS QTOF, with the to be added to the method, as long as the QC
QTOF having the additional capability to requirements are met. Simultaneous qualitative and
simultaneously screen for potential unknown PFAS quantitative analysis allows for laboratories to
contaminants with a streamlined workflow using constantly screen for PFAS not specifically in EPA
LabSolutions Insight Explore. Method 537.1, while quantifying known PFAS
contaminants.

■ Reference
• EPA Method 537.1, Determination of selected per- and polyfluorinated alkyl substances in drinking water
by solid phase extraction and liquid chromatography/tandem mass spectrometry (LC/MS/MS), Version 1.0.
(U.S. Environmental Protection Agency, Washington, D.C., Nov.2018).